Sam Pleasure, MD, PhD

Professor of Neurology
Neurology
+1 415 514-4949
Publications: 

Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms.

Cell reports. Medicine

Song E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Sunshine S, Liu J, Wu W, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Goldman-Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander JR, Gallego JA, Lencz T, Walsh H, Wapniarski AE, Mohanty S, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, Pak J, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF

Remission of Subacute Psychosis in a COVID-19 Patient With an Antineuronal Autoantibody After Treatment With Intravenous Immunoglobulin.

Biological Psychiatry

McAlpine LS, Lifland B, Check JR, Angarita GA, Ngo TT, Pleasure SJ, Wilson MR, Spudich SS, Farhadian SF, Bartley CM

NMDA receptors control development of somatosensory callosal axonal projections.

eLife

Zhou J, Lin Y, Huynh T, Noguchi H, Bush JO, Pleasure S

The neocortical progenitor specification program is established through combined modulation of SHH and FGF signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Yabut OR, Ng HX, Yoon K, Arela JC, Ngo T, Pleasure SJ

ANA Investigates: Pioneering Unbiased Diagnostics.

Annals of neurology

Richie M, Pleasure S, Hurley J, Goss A, Wilson M

Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis.

The New England journal of medicine

Mandel-Brehm C, Dubey D, Kryzer TJ, O'Donovan BD, Tran B, Vazquez SE, Sample HA, Zorn KC, Khan LM, Bledsoe IO, McKeon A, Pleasure SJ, Lennon VA, DeRisi JL, Wilson MR, Pittock SJ

Foxg1 Regulates the Postnatal Development of Cortical Interneurons.

Cerebral cortex (New York, N.Y. : 1991)

Shen W, Ba R, Su Y, Ni Y, Chen D, Xie W, Pleasure SJ, Zhao C

Meningeal Bmps Regulate Cortical Layer Formation.

Brain plasticity (Amsterdam, Netherlands)

Choe Y, Pleasure SJ

FoxG1 Directly Represses Dentate Granule Cell Fate During Forebrain Development.

Frontiers in cellular neuroscience

Han X, Gu X, Zhang Q, Wang Q, Cheng Y, Pleasure SJ, Zhao C

Ttyh1 regulates embryonic neural stem cell properties by enhancing the Notch signaling pathway.

EMBO reports

Kim J, Han D, Byun SH, Kwon M, Cho JY, Pleasure SJ, Yoon K

Sonic Hedgehog Signaling Rises to the Surface: Emerging Roles in Neocortical Development.

Brain plasticity (Amsterdam, Netherlands)

Yabut OR, Pleasure SJ

Impaired Organization of GABAergic Neurons Following Prenatal Hypoxia.

Neuroscience

Nisimov H, Orenbuch A, Pleasure SJ, Golan HM

The Dorsal Wave of Neocortical Oligodendrogenesis Begins Embryonically and Requires Multiple Sources of Sonic Hedgehog.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Winkler CC, Yabut OR, Fregoso SP, Gomez HG, Dwyer BE, Pleasure SJ, Franco SJ

Focal cerebral ß-amyloid angiopathy: A distinct clinicopathologic presentation.

Neurology. Clinical practice

Karageorgiou E, Naasan G, Pleasure SJ, Alexandrescu S, Gelfand JM, Tammewar G, Miller BL, Rabinovici GD, Grinberg LT

TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway.

Development (Cambridge, England)

Byun SH, Kim J, Han D, Kwon M, Cho JY, Ng HX, Pleasure SJ, Yoon K

TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation.

Neuron

Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN

The Crossroads of Neural Stem Cell Development and Tumorigenesis.

Opera medica et physiologica

Yabut OR, Pleasure SJ

Loss of Suppressor of Fused in Mid-Corticogenesis Leads to the Expansion of Intermediate Progenitors.

Journal of developmental biology

Yabut OR, Ng HX, Fernandez G, Yoon K, Kuhn J, Pleasure SJ

Diverse Functions of Retinoic Acid in Brain Vascular Development.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Bonney S, Harrison-Uy S, Mishra S, MacPherson AM, Choe Y, Li D, Jaminet SC, Fruttiger M, Pleasure SJ, Siegenthaler JA

Cell Type-Specific Circuit Mapping Reveals the Presynaptic Connectivity of Developing Cortical Circuits.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Cocas LA, Fernandez G, Barch M, Doll J, Zamora Diaz I, Pleasure SJ

Control of Adult Neurogenesis by Short-Range Morphogenic-Signaling Molecules.

Cold Spring Harbor perspectives in biology

Choe Y, Pleasure SJ, Mira H

A Notch above Sonic Hedgehog.

Developmental cell

Yabut O, Pleasure SJ, Yoon K

Migration of oligodendrocyte progenitor cells is controlled by transforming growth factor ß family proteins during corticogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Choe Y, Huynh T, Pleasure SJ

Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Berberoglu MA, Dong Z, Li G, Zheng J, Trejo Martinez Ldel C, Peng J, Wagle M, Reichholf B, Petritsch C, Li H, Pleasure SJ, Guo S

Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology.

Nature communications

Orosco LA, Ross AP, Cates SL, Scott SE, Wu D, Sohn J, Pleasure D, Pleasure SJ, Adamopoulos IE, Zarbalis KS

The quintessence of quiescence.

Neuron

Yabut O, Pleasure SJ

Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons.

Development (Cambridge, England)

Yang S, Edman LC, Sánchez-Alcañiz JA, Fritz N, Bonilla S, Hecht J, Uhlén P, Pleasure SJ, Villaescusa JC, Marín O, Arenas E

The development of hippocampal cellular assemblies.

Wiley interdisciplinary reviews. Developmental biology

Li G, Pleasure SJ

Importance and hurdles to drug discovery for neurological disease.

Annals of neurology

Berger JR, Choi D, Kaminski HJ, Gordon MF, Hurko O, D'Cruz O, Pleasure SJ, Feldman EL

A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting.

PloS one

Ross AP, Mansilla MA, Choe Y, Helminski S, Sturm R, Maute RL, May SR, Hozyasz KK, Wójcicki P, Mostowska A, Davidson B, Adamopoulos IE, Pleasure SJ, Murray JC, Zarbalis KS

Foxc1 is required by pericytes during fetal brain angiogenesis.

Biology open

Siegenthaler JA, Choe Y, Patterson KP, Hsieh I, Li D, Jaminet SC, Daneman R, Kume T, Huang EJ, Pleasure SJ

Bone morphogenic protein signaling is a major determinant of dentate development.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Choe Y, Kozlova A, Graf D, Pleasure SJ

CoupTFI interacts with retinoic acid signaling during cortical development.

PloS one

Harrison-Uy SJ, Siegenthaler JA, Faedo A, Rubenstein JL, Pleasure SJ

Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream.

Nature neuroscience

Huilgol D, Udin S, Shimogori T, Saha B, Roy A, Aizawa S, Hevner RF, Meyer G, Ohshima T, Pleasure SJ, Zhao Y, Tole S

The GAP between axon pruning and repulsion.

Developmental cell

Choe Y, Pleasure SJ

Wnt signaling and forebrain development.

Cold Spring Harbor perspectives in biology

Harrison-Uy SJ, Pleasure SJ

Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.

Neuron

Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN

Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA.

Proceedings of the National Academy of Sciences of the United States of America

Jung HJ, Coffinier C, Choe Y, Beigneux AP, Davies BS, Yang SH, Barnes RH, Hong J, Sun T, Pleasure SJ, Young SG, Fong LG

Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice.

Neural development

Zarbalis K, Choe Y, Siegenthaler JA, Orosco LA, Pleasure SJ

Inducible genetic lineage tracing of cortical hem derived Cajal-Retzius cells reveals novel properties.

PloS one

Gu X, Liu B, Wu X, Yan Y, Zhang Y, Wei Y, Pleasure SJ, Zhao C

An inducible transgenic Cre mouse line for the study of hippocampal development and adult neurogenesis.

Genesis (New York, N.Y. : 2000)

Li Y, Tian C, Yang Y, Yan Y, Ni Y, Wei Y, Pleasure SJ, Zhao C

Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke.

Translational stroke research

Jiang L, Shen F, Degos V, Schonemann M, Pleasure SJ, Mellon SH, Young WL, Su H

Wnt signaling regulates neuronal differentiation of cortical intermediate progenitors.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Munji RN, Choe Y, Li G, Siegenthaler JA, Pleasure SJ

We have got you 'covered': how the meninges control brain development.

Current opinion in genetics & development

Siegenthaler JA, Pleasure SJ

CXCR4 and CXCR7 have distinct functions in regulating interneuron migration.

Neuron

Wang Y, Li G, Stanco A, Long JE, Crawford D, Potter GB, Pleasure SJ, Behrens T, Rubenstein JL

Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression.

Proceedings of the National Academy of Sciences of the United States of America

Pozniak CD, Langseth AJ, Dijkgraaf GJ, Choe Y, Werb Z, Pleasure SJ

Wnts influence the timing and efficiency of oligodendrocyte precursor cell generation in the telencephalon.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Langseth AJ, Munji RN, Choe Y, Huynh T, Pozniak CD, Pleasure SJ

Primary cellular meningeal defects cause neocortical dysplasia and dyslamination.

Annals of neurology

Hecht JH, Siegenthaler JA, Patterson KP, Pleasure SJ

There's no place like home for a neural stem cell.

Cell stem cell

Siegenthaler JA, Pleasure SJ

A transgenic Cre mouse line for the study of cortical and hippocampal development.

Genesis (New York, N.Y. : 2000)

Zhou W, Zhang Y, Li Y, Wei YS, Liu G, Liu DP, Pleasure SJ, Xie W, Zhao C

Retinoic acid from the meninges regulates cortical neuron generation.

Cell

Siegenthaler JA, Ashique AM, Zarbalis K, Patterson KP, Hecht JH, Kane MA, Folias AE, Choe Y, May SR, Kume T, Napoli JL, Peterson AS, Pleasure SJ

Wnt signaling in development and disease.

Neurobiology of disease

Freese JL, Pino D, Pleasure SJ

Isoflurane inhibits growth but does not cause cell death in hippocampal neural precursor cells grown in culture.

Anesthesiology

Sall JW, Stratmann G, Leong J, McKleroy W, Mason D, Shenoy S, Pleasure SJ, Bickler PE

Genes and signaling events that establish regional patterning of the mammalian forebrain.

Seminars in cell & developmental biology

Hoch RV, Rubenstein JL, Pleasure S

Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes.

Developmental dynamics : an official publication of the American Association of Anatomists

Zhou CJ, Molotkov A, Song L, Li Y, Pleasure DE, Pleasure SJ, Wang YZ

Generation of Frizzled10-Cre transgenic mouse line: a useful tool for the study of dorsal telencephalic development.

Genesis (New York, N.Y. : 2000)

Gu X, He D, Li Y, Hu C, Wei YS, Liu G, Liu D, Pleasure SJ, Xie W, Zhao C

NMDA receptors inhibit synapse unsilencing during brain development.

Proceedings of the National Academy of Sciences of the United States of America

Adesnik H, Li G, During MJ, Pleasure SJ, Nicoll RA

Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Li G, Adesnik H, Li J, Long J, Nicoll RA, Rubenstein JL, Pleasure SJ

COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.

Cerebral cortex (New York, N.Y. : 1991)

Faedo A, Tomassy GS, Ruan Y, Teichmann H, Krauss S, Pleasure SJ, Tsai SY, Tsai MJ, Studer M, Rubenstein JL

Hilar mossy cells share developmental influences with dentate granule neurons.

Developmental neuroscience

Li G, Berger O, Han SM, Paredes M, Wu NC, Pleasure SJ

Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development.

Proceedings of the National Academy of Sciences of the United States of America

Zarbalis K, Siegenthaler JA, Choe Y, May SR, Peterson AS, Pleasure SJ

Expression of SDF-1 and CXCR4 during reorganization of the postnatal dentate gyrus.

Developmental neuroscience

Berger O, Li G, Han SM, Paredes M, Pleasure SJ

Genetic regulation of dentate gyrus morphogenesis.

Progress in brain research

Li G, Pleasure SJ

Pneumococcal meningitis induces apoptosis in recently postmitotic immature neurons in the dentate gyrus of neonatal rats.

Developmental neuroscience

Grandgirard D, Bifrare YD, Pleasure SJ, Kummer J, Leib SL, Tauber MG

Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Paredes MF, Li G, Berger O, Baraban SC, Pleasure SJ

Genetic control of hippocampal neurogenesis.

Genome biology

Pozniak CD, Pleasure SJ

A tale of two signals: Wnt and Hedgehog in dentate neurogenesis.

Science's STKE : signal transduction knowledge environment

Pozniak CD, Pleasure SJ

Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy.

Annals of neurology

Parent JM, Elliott RC, Pleasure SJ, Barbaro NM, Lowenstein DH

Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval.

Development (Cambridge, England)

Zhao C, Avilés C, Abel RA, Almli CR, McQuillen P, Pleasure SJ

Laminar organization of the mouse dentate gyrus: insights from BETA2/Neuro D mutant mice.

The Journal of comparative neurology

Del Turco D, Gebhardt C, Burbach GJ, Pleasure SJ, Lowenstein DH, Deller T

Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Zhou CJ, Pinson KI, Pleasure SJ

Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Zhou CJ, Zhao C, Pleasure SJ

Expression of the BMP antagonist Dan during murine forebrain development.

Brain research. Developmental brain research

Kim AS, Pleasure SJ

ATP-binding cassette transporter ABCA2 (ABC2) expression in the developing spinal cord and PNS during myelination.

The Journal of comparative neurology

Zhou CJ, Inagaki N, Pleasure SJ, Zhao LX, Kikuyama S, Shioda S

The chemokine SDF1 regulates migration of dentate granule cells.

Development (Cambridge, England)

Bagri A, Gurney T, He X, Zou YR, Littman DR, Tessier-Lavigne M, Pleasure SJ

PACAP and its receptors exert pleiotropic effects in the nervous system by activating multiple signaling pathways.

Current protein & peptide science

Zhou CJ, Shioda S, Yada T, Inagaki N, Pleasure SJ, Kikuyama S

Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.

Neuron

Bagri A, Marín O, Plump AS, Mak J, Pleasure SJ, Rubenstein JL, Tessier-Lavigne M

Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

Neuron

Cheng HJ, Bagri A, Yaron A, Stein E, Pleasure SJ, Tessier-Lavigne M

Wnt receptors and Wnt inhibitors are expressed in gradients in the developing telencephalon.

Mechanisms of development

Kim AS, Lowenstein DH, Pleasure SJ

Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kim AS, Anderson SA, Rubenstein JL, Lowenstein DH, Pleasure SJ

An arrow hits the Wnt signaling pathway.

Trends in neurosciences

Pleasure SJ

Differential regulation of basic helix-loop-helix mRNAs in the dentate gyrus following status epilepticus.

Neuroscience

Elliott RC, Khademi S, Pleasure SJ, Parent JM, Lowenstein DH

Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons.

Neuron

Pleasure SJ, Anderson S, Hevner R, Bagri A, Marin O, Lowenstein DH, Rubenstein JL

Unique expression patterns of cell fate molecules delineate sequential stages of dentate gyrus development.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Pleasure SJ, Collins AE, Lowenstein DH

Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy.

Proceedings of the National Academy of Sciences of the United States of America

Liu M, Pleasure SJ, Collins AE, Noebels JL, Naya FJ, Tsai MJ, Lowenstein DH

Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections.

Neuron

Chen H, Bagri A, Zupicich JA, Zou Y, Stoeckli E, Pleasure SJ, Lowenstein DH, Skarnes WC, Chédotal A, Tessier-Lavigne M

Spontaneous intracranial hypotension resulting in stupor caused by diencephalic compression.

Neurology

Pleasure SJ, Abosch A, Friedman J, Ko NU, Barbaro N, Dillon W, Fishman RA, Poncelet AN

Glial cells of the lamprey nervous system contain keratin-like proteins.

The Journal of comparative neurology

Merrick SE, Pleasure SJ, Lurie DI, Pijak DS, Selzer ME, Lee VM

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.

Proceedings of the National Academy of Sciences of the United States of America

Wertkin AM, Turner RS, Pleasure SJ, Golde TE, Younkin SG, Trojanowski JQ, Lee VM

Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.

Proceedings of the National Academy of Sciences of the United States of America

Younkin DP, Tang CM, Hardy M, Reddy UR, Shi QY, Pleasure SJ, Lee VM, Pleasure D

Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Pleasure SJ, Page C, Lee VM

Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts.

Laboratory investigation; a journal of technical methods and pathology

He XM, Wikstrand CJ, Friedman HS, Bigner SH, Pleasure S, Trojanowski JQ, Bigner DD

Introduction of nerve growth factor (NGF) receptors into a medulloblastoma cell line results in expression of high- and low-affinity NGF receptors but not NGF-mediated differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Pleasure SJ, Reddy UR, Venkatakrishnan G, Roy AK, Chen J, Ross AH, Trojanowski JQ, Pleasure DE, Lee VM

Human central nervous system primitive neuroectodermal tumor expressing nerve growth factor receptors: CHP707m.

Annals of neurology

Baker DL, Reddy UR, Pleasure S, Hardy M, Williams M, Tartaglione M, Biegel JA, Emanuel BS, Lo Presti P, Kreider B

Site-specific phosphorylation of the middle molecular weight human neurofilament protein in transfected non-neuronal cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Pleasure SJ, Lee VM, Nelson DL

Lamprey neurofilaments combine in one subunit the features of each mammalian NF triplet protein but are highly phosphorylated only in large axons.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Pleasure SJ, Selzer ME, Lee VM