Junior Specialist - Fujimori Lab

The appointed individual will be required to accurately document all experiments and will need to have excellent written and verbal communications. Candidates interested in obtaining research experience prior to applying to graduate school and those who prefer long term technician position are encouraged to apply.

Required Qualifications:

• A bachelor’s degree in biochemistry, chemistry, chemical biology or a related field or at least four years of research experience.
• Excellent ability to document experiments and to communicate (written and verbal)
• Prior research experience
• Ability to work as a member of a dynamic, interdisciplinary team
• Motivation for scientific research and strong work ethics
• Candidates must meet the required qualifications at the time of appointment.
• Candidate’s CV/cover must state required qualifications (or if pending) upon submission.

Preferred Qualifications:

• Research experience in chemical biology, biochemistry or chemistry
• One year of research experience in academia or industry

Please apply online at https://aprecruit.ucsf.edu/JPF05091, with a CV, cover letter, and two references.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$54,600.

The Larson Lab is seeking a Junior, Assistant, Associate, or Full Specialist. This position is focused on using modern machine learning and computer vision algorithms for automated large-scale analyses of cancer imaging data, working with Dr. Thomas Hope (https://profiles.ucsf.edu/thomas.hope) and Prof. Peder Larson (http://www.radiology.ucsf.edu/research/labs/larson).

More specifically, positron emission tomography (PET) with prostate-specific membrane antigen (PSMA) based agents is transforming the assessment of lethal advanced prostate cancers. UCSF and Dr. Thomas Hope have led the clinical translation of this agent, and a key next step is to develop advanced tools for analyzing PSMA PET data. This promises to maximize the utility by improving our understanding how the measurements in PSMA PET images in relation to diseases progression and treatments.

We propose to develop such advanced analysis tools using modern machine learning and computer vision methods to automatically segment and classify lesions as well as provide quantitative measures of localized disease burden.

The responsibilities of this position include:

• Curation and management of cancer imaging datasets
• Integration of information from clinical databases and clinicians
• Training machine learning models using cancer imaging datasets

Required Qualifications:

• Specialists appointed at the Junior rank must possess a baccalaureate degree in Computer Science, Electrical Engineering, Data Science, (or equivalent degree or related field) or at least four years of research experience.
• Specialists appointed at the Assistant rank must possess a master’s degree (or equivalent degree) or a baccalaureate degree with three or more years of research experience.
• Specialists appointed at the Associate rank must possess a master’s degree (or equivalent degree) or five to ten years of research experience.
• Specialists appointed at the Full rank must possess a terminal degree (or equivalent degree) or ten or more years of research experience.
• Must have strong written and verbal communication skills.
• Ability to work on collaborative research projects in a multi-disciplinary team.
• Applicants must meet all of the requirements by the time of hire.
• Applicant materials must list current and/or pending qualifications upon submission.

Preferred Qualifications:

• Experience with Python and PyTorch
• Setting up and curating large datasets
• Computer vision model development
• Training of Machine Learning models
• Training of Machine Learning models based on image data

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$181,800.

Please apply online at: https://aprecruit.ucsf.edu/JPF05026 with a cover letter, CV, and contact information for two references.

Junior/Assistant Specialist - Nowakowski Lab

The Nowakowski lab is looking for motivated individuals to join the team at the UCSF Mission Bay campus. As a research scientist, you will join a rapidly evolving team to develop tools and technologies for studying brain development for the NIH-funded BRAIN Initiative and Chan-Zuckerberg Human Cell Atlas projects, among others. Your responsibilities will include but will not be limited to designing, developing, and optimizing molecular tools for studying development of the cerebral cortex, and scalable molecular tools for studying psychiatric disease candidate mutations on brain development. You will be training people how to use equipment and deploy technologies across projects within the laboratory, and across the collaborating groups.

Required Qualifications:

• Specialists appointed at the junior rank must possess (or in process of obtaining) a baccalaureate degree (or equivalent degree) or at least four years of research experience (e.g., with instrumentation and research equipment, social science research methods, or creative activities).
• Specialists appointed at the Assistant rank must possess (or in process of obtaining) a Master’s degree (or equivalent degree) or a baccalaureate degree with 3 or more years of research experience.
• Applicants must have obtained the degree requirement for the Specialist rank by the time of hire.
• Applicants’ materials must list current and/or pending qualifications upon submission.
• Excellent interpersonal, collaborative, and communication skills are expected, as well as attention to details and high organizational, documentation and time management skills.
• We are looking for candidates who can work independently and are self-motivated but are also able to excel in a highly collaborative environment.

Preferred Qualifications:

• Prefer degree in Biochemistry, Molecular Biology, Neuroscience, or a related field.
• At least one year of working with a cellular, tissue or animal model of brain such as brain organoids is highly encouraged.
• Expertise in molecular biology, cloning, and viral tool design is encouraged.
• Experience in fluorescence microscopy (such as confocal), in situ hybridization, sequencing library construction are highly encouraged.
• Some experience in Next-Gen Sequencing and bioinformatics is encouraged.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300 - $65,900.

Please apply online at https://aprecruit.ucsf.edu/JPF05116.

Junior Specialist - Knox Lab

The Knox Lab is seeking a Junior Specialist to join the group and contribute to new and ongoing research focused on dry eye disease and nerve-tissue interactions in the cornea. Using an autoimmune disease mouse as our model system, we study the cellular and molecular basis of dry eye and the mechanisms of chronic injury and cornea regeneration. The candidate will be expected to contribute to these research directions, by using techniques including mouse genetics, molecular biology, immunohistochemistry, 3D imaging, bioinformatics, etc. An exception candidate will lead their own independent project, be familiar with the literature, develop new ideas, and participate in procurement of funds, where appropriate. Additionally, the Junior Specialist will be expected to assist with managing day-to-day operations, and perform general lab duties and be a positive lab citizen. Depending on performance and workload, mentorship of other trainees, and scientific writing will be available.

Required Qualifications:

• Must have (or be in process of obtaining) a baccalaureate degree (or equivalent degree) or at least four years of research experience to be appointed at the Junior rank.
• Excellent organizational and interpersonal communication skills (verbal and written).
• Willingness and ability to learn new methods and skills for changing research priorities.
• Ability to work independently and as a member of a research team.
• Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.

We are seeking an 18-month to 2-year commitment. We are committed to fostering a diverse, equitable, and inclusive workplace in our lab, and welcome applicants from underrepresented backgrounds to join us.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$54,600.

Please apply online at https://aprecruit.ucsf.edu/JPF05007 with CV and contact information for two references. Applicant materials must list current and/or pending qualifications upon submission. The selected candidate must meet all of the qualifications at the time of appointment.

Junior/Assistant/Associate/Full Specialist - Nystul Lab

The Nystul lab is seeking a Junior/Assistant/Associate/Full Specialist to join our group and contribute to new and ongoing projects. Our lab focuses on epithelial stem cells using Drosophila melanogaster as a model. The successful applicant will design and perform experiments to investigate mechanisms of competition for an epithelial stem cell niche using the Drosophila as a model. The applicant will develop a detailed understanding of Drosophila genetics, Drosophila oogenesis, stem cell biology, and epithelial biology. An exceptional candidate will lead their own independent project, develop new ideas, be familiar with the literature, and participate in procurement of funds, where appropriate. Additionally, the specialist will be expected to assist with managing day-to-day lab operations, and perform general lab duties and be a positive lab citizen.

Required Qualifications:

• Excellent organizational and interpersonal communication skills (verbal and written)
• Willingness and ability to learn new methods and skills for changing research priorities.
• Ability to work independently and as a member of a research team.
• Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.
• Must have (or be in process of obtaining) a baccalaureate degree (or equivalent degree) or four years of research experience to be appointed at the Junior rank.
• Must have (or be in process of obtaining) a master’s degree (or equivalent degree) or a baccalaureate degree with three or more years of research experience to be appointed at the Assistant rank.
• Must have (or be in process of obtaining) a master’s degree (or equivalent degree) or at least five to ten years of research experience to be appointed at the Associate rank.
• Must have (or be in process of obtaining) a terminal degree (or equivalent degree) or at least ten or more years of research experience to be appointed at the Full rank.

Preferred Qualifications:

• Experience with laboratory research using Drosophila as an experimental model
• Experience with whole-mount tissue immunofluorescence
• Knowledge of the developmental properties of cells and tissues
• Experience with identifying and reviewing relevant scientific literature
• Experience with developing and writing wet-lab protocols
• Knowledge about research design, ethics in research, and data presentation

We are seeking at least a 1-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available.

Applicants must meet requirements by the time of appointment.

Please apply online at https://aprecruit.ucsf.edu/JPF04928.

Junior Specialist - Padmanabahn Lab

The Padmanabhan Lab is now recruiting a Junior Specialist. The areas of specialization and responsibilities for this position include:
• Culture and genetically manipulate mouse embryonic stem (mES) and human induced pluripotent stem (hIPS) cells and perform directed differentiation to atrial and ventricular cardiomyocytes.
• Design, generate, and validate novel genotyping protocols for engineered mouse genetic alleles and cell lines.
• Assessment gene expression by quantitative PCR.
• Perform timed matings and dam dissections to isolate mouse embryos at various stages of development.
• Perform rapid DNA isolation and genotyping of mouse embryos immediately following sample collection.
• Process embryonic and adult tissues for histologic evaluation.
• Perform standard molecular biology and biochemistry techniques (including molecular cloning, virus preparation and in vitro/in vivo viral transduction, Western blotting, immunoprecipitation, co-immunoprecipitation, and chromatin immunoprecipitation).
• Organize and actively maintain a mouse colony of 80-100 cages.
• Collaborate with other laboratory staff to rapidly complete necessary tasks and move research program forward.
• Maintain a pristine laboratory notebook and organize all collected data and samples appropriately.
• Perform basic statistical analysis, organize collected data into a presentable format, and summarize findings in narrative form.

Required qualifications:
• Bachelor’s Degree in Biological Sciences, Bioengineering, or related fields.
• At least 1-year of experience working in a research laboratory in either academia or industry settings.
• Knowledge of cell culture, standard molecular biology and biochemistry techniques, and in vivo mouse modeling.
• Demonstrated ability to contribute data to ongoing research efforts.
• Skill in independently resolving broad problems that may arise in collection or analysis of laboratory data.
• Self-motivated with ability to work independently and as part of a team.
• Able to learn effectively and meet deadlines.
• Demonstrated effective communication and interpersonal skills.
• Proven ability to successfully work on multiple concurrent projects.
• Ability to effectively manage their time.
• Proven ability to understand research cycles and rapidly perform experiments necessary for manuscripts in revision.
• Interest and proven ability to work closely with other members of the team towards carrying out the broader goals of the laboratory.

Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service. Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary will be commensurate with the applicants experience and training.

Please apply online at https://aprecruit.ucsf.edu/JPF04804. Applicants’ materials must list current and/or pending qualifications upon submission.

Junior/Assistant/Associate/Full Specialist - Singh Lab

SCHOOL OF MEDICINE – Department of Anatomy

Description

The Singh Lab at UCSF (www.singhlabucsf.org) is seeking a highly motivated Junior/Assistant/Associate/Full Specialist to join our research program at the intersection of aging biology, genomics, and machine learning. Our lab is tackling the fundamental questions in the field of aging using a multi-disciplinary approach. We integrate cutting-edge single-cell RNA sequencing (scRNA-seq) and other multi-omics datasets with advanced machine learning techniques to decipher the intricate genomic changes that drive aging and age-related diseases. We not only work with human and mouse data – we're also exploring the remarkable biology of the African killifish, a powerful model organism for aging research. By comparing genomic patterns across species, we aim to identify conserved processes that underlie aging and develop innovative strategies to promote healthy lifespan.

As a Junior/Assistant/Associate/Full Specialist in our lab, you will:

• Spearhead the development and application of novel AI/ML algorithms to analyze large-scale scRNA-seq datasets related to aging.
• Uncover hidden patterns and predict age-related changes and 'aging clocks' at the single-cell level.
• Identify key genes, pathways, and cell types that contribute to aging and age-related diseases.
• Collaborate with a dynamic team of researchers with multi-disciplinary expertise in genomics, bioinformatics, and aging biology.
• Contribute to a vibrant research community at UCSF, including the Bakar Aging Research Institute (BARI) and the Bakar Computational Health Sciences Institute (BCHSI).

Required qualifications:

• Must have (or be in process of obtaining) a bachelor’s degree (or equivalent degree) or four years of research experience to be appointed at the Junior rank.
• Must have (or be in process of obtaining) a master’s degree (or equivalent degree) or a bachelor's degree with three or more years of research experience to be appointed at the Assistant rank.
• Must have (or be in process of obtaining) a master's degree (or equivalent degree) five to ten years of research experience to be appointed at the Associate rank.
• Must have (or be in process of obtaining) a terminal degree (or equivalent degree) or at least ten or more years of research experience to be appointed at the Full rank.

Preferred Qualification:

• Proven experience analyzing scRNA-seq, scATAC-seq or spatial-RNA-seq data.
• Proven experience expertise in AI/ML applied to genomic data.
• Proficiency in Python and relevant libraries for machine learning (e.g., scikit-learn, TensorFlow, PyTorch).

We will consider applications on a rolling basis until all positions are filled. We are seeking at least a 2-year commitment. Applicants must meet requirements by the time of the appointment.

Please apply online at https://aprecruit.ucsf.edu/JPF05498

See Table 24B for the salary range for this position. A reasonable estimate for this position is $53,100-$188,200.

Research Specialist - Sangokoya Lab

The Sangokoya Lab at the University of California, San Francisco (UCSF) Parnassus campus has an opening for a research specialist. The lab is centered on 1) the investigation of two-dimensional and three-dimensional mammalian stem cell models (basic stem cell biology) and 2) human liver pathobiology (liver pathology, cell-based tissue culture models). Both areas focus on the biological effects of RNA-based regulation on development, biology, and disease both in-vitro and in-vivo models as well as human tissue.

A research specialist in the Sangokoya Lab will be a key laboratory member assisting with management of daily operations of the lab, assisting with ongoing experiments, and acting as an interfacing point of contact for lab activities and maintenance as necessary. The ideal candidate will have a high level of organization and be a strong communicator, ensuring compliance with all regulatory requirements, including maintaining laboratory spaces and equipment. Additionally, the candidate will have the opportunity to contribute, learn, and utilize a variety of research techniques as aligned with previous experience, skills, and expertise.

All specialist responsibilities include but are not limited to:

• Administrative lab duties including; lab schedules, staff onboarding, and ensuring compliance with safety guidelines.
• Manage daily lab operations including; organizing the lab space, maintaining a sterile and well-stocked lab environment, inventory, ensuring equipment and maintenance.
• Assist with research projects, with the capability to work independently.
• Have and maintain up-to-date general knowledge of molecular biology techniques as necessary to complete tasks and projects.
• If background is wet-lab-based, should have or be amenable to acquiring basic computational biology (analysis) skills including analysis of sequencing datasets (RNA-seq, single-cell RNA-seq, spatial analysis), image-based analysis (i.e. Imaris, ImageJ, FIJI-based programs). Other knowledge areas (protein-based, chemical biology, engineering) considered as related to current opportunities in lab.
• Additional responsibilities may include: performing molecular biology techniques including RNA/DNA extraction, PCR, basic protein preparations/analysis (i.e. western blot) plasmid preparation and basic cloning, performing imaging/cytometry techniques including immunofluorescence, immunohistochemistry, flow cytometry, performing basic data analysis, scientific writing, mouse work including handling/imaging/dissection. Prior experience in these areas are highly valued, but comparable expertise and skills in relevant scientific areas not listed will be considered.

The specialist will be expected to work well as part of a team, yet be able to work independently with high regard for rigorous standards. The specialist will have enthusiasm for the practice of science, and be a positive lab citizen. This position is ideal for a candidate with a background in laboratory-based biology or complementary scientific backgrounds including molecular biology, bioengineering, biochemistry, and chemical biology.

Required Qualifications:

• Specialists appointed at the junior rank must possess a Baccalaureate degree (or equivalent degree) or at least four years of research experience.
• Specialists appointed at the Assistant rank must possess a Master’s degree or a baccalaureate degree with 3 or more years of research experience.
• Specialists appointed at the Associate rank must possess a Master’s degree (or equivalent degree) or five to ten years of experience in the relevant specialization.
• Specialists appointed at the full rank must possess a terminal degree (or equivalent degree) or ten or more years of experience in the relevant specialization.
• Excellent organizational and analytical skills.
• Excellent interpersonal communication (verbal and written).
• Ability to work independently, prioritize and coordinate tasks, and meet multiple deadlines.
• Applicant must have all requirements met by time of hire.
• Applicants’ materials must list current and/or pending qualifications upon submission.

Preferred Qualifications:

• Prior laboratory-based research experience.
• Prior experience with data analysis and/or image analysis, molecular biology and biochemistry techniques, cell culture ----are considered a plus.
• If background is wet-lab-based, the specialist should have or be amenable to acquiring basic computational biology (analysis) skills including analysis of sequencing datasets (RNA-seq, single-cell RNA-seq, spatial analysis), image-based analysis (i.e. Imaris, ImageJ, FIJI-based programs). Other knowledge areas (protein-based, chemical biology, engineering) considered as related to current opportunities in lab.
• Experience in microscopy, imaging; confocal or other advanced microscopy preferred.
• Experience in programming/coding-based analysis of datasets using R-based (or other programming language) programs.
• Scientific curiosity and a strong motivation to contribute to the field.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $53,100 - $188,200.

Please apply online at https://aprecruit.ucsf.edu/JPF05414.

Junior Specialist- Calderon Lab

The Department of Bioengineering & Therapeutic Sciences is now recruiting a Junior Specialist. The position duties including performing molecular biology techniques including RNA/DNA extraction, PCR, plasmid preparation, basic cloning, NGS library prep, gel electrophoresis, tissue culture, performing basic sequence data analysis, scientific writing, organization of data appropriate to role in the lab, record keeping and data entry, and shared lab manager/organizational duties. Exceptional candidates will lead their own independent project(s), develop new ideas, be familiar with the literature, and participate in procurement of funds, where appropriate.

Required Qualifications:

• A bachelor’s degree (or equivalent degree) or at least four years of research experience. A bachelor's degree may be in progress if the expected completion date will be before the start of the position.
• A background in molecular biology
• Must have strong written and verbal communication skills.
• Willingness and ability to learn new methods and skills for changing research priorities.
• Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.
• Ability to work independently and as a member of a research team.
• Candidates must meet the required qualifications at the time of appointment.
• Application materials must state qualifications and/or if pending upon submission.

Preferred Qualifications:

• Candidates interested in applying to graduate or medical school are encouraged to apply.
• At least a 2-year commitment.

Please apply online at https://aprecruit.ucsf.edu/JPF05145.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $53,100-$56,600.

The McManus lab is looking for a candidate to be open to learning new methods and must have excellent communication skills, as this position requires teamwork in a laboratory environment. The position represents an excellent opportunity for basic laboratory and research skills in a dynamic environment. The successful applicant will be an energetic, team player, self-directed learner with a keen interest in research.

Under direct supervision and with guidance from senior lab members, the employee will be expected to perform experiments to support lab members research. The specific types of experiments will vary and include assisting high throughput microscopy and the use state of the other technologies located in the PCAT (robotics, cytometry, plate reader, etc). Assist the PI in overseeing ViraCore activities. This duty will involve teaching cell culture, virus production, and related tasks to ViraCore staff members.

Required Qualifications:

• Specialists appointed at the junior rank must possess (or in the process of obtaining) a baccalaureate degree (or equivalent degree) in Neuroscience, Behavior, Physiology, Biology, Molecular Biology, or a related science or at least four years of research experience.
• Specialists appointed at the Assistant rank must possess (or in the process of obtaining) a master’s degree in Neuroscience, Behavior, Physiology, Biology, Molecular Biology, or a related science or a baccalaureate degree with 3 or more years of research experience.
• Specialists appointed at the Associate rank must possess (or in the process of obtaining) a master’s degree (or equivalent degree) in Neuroscience, Behavior, Physiology, Biology, Molecular Biology, or a related science or five to ten years of experience in the relevant specialization.
• Specialists appointed at the full rank must possess (or in the process of obtaining) a terminal degree (or equivalent degree) in Neuroscience, Behavior, Physiology, Biology, Molecular Biology, or a related science or ten or more years of experience in the relevant specialization.
• Applicants must meet requirements by the time of hire.
• Applicants’ materials must list current and/or pending qualifications upon submission.
• Experience in basic molecular biology protocols, including PCR and qPCR (may be that which is acquired while in school).
• Experience with Biomek robotics instrumentation.
• Experience and/or motivation to work with small animals/mouse colony.
• Experience with high content microscopy.
• Expertise in cell culture and lentivirus preparation.
• Knowledge/experience with basic techniques/methods required by the position; or an equivalent combination of education and experience.
• Practical laboratory experience, such as benchwork in biomedical research laboratory (may include undergraduate experience.
• Effective use of laboratory instruments and their maintenance; knowledge of biomedical and biotechnological techniques and methodologies.
• Basic understanding of trouble-shooting experiments and problem solving.
• Data analysis and interpretation skills.
• Excellent verbal and written communication skills, initiative to work independently and efficiently.
• Ability to trouble-shoot experiments.
• Ability to analyze data in spreadsheets.
• Ability to handle and prioritize responsibilities pertaining to multiple projects.

Preferred Qualifications:

• Basic skills in statistical analysis and the use of relevant statistical software such as R.
• Ability to prepare scientific figures using Power Point, Adobe Illustrator, and/or similar programs.

Please apply online at https://aprecruit.ucsf.edu/JPF04736.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300 - $181,800.

Research Specialist - Marson Lab

About the role:

The Marson Lab at the Gladstone-UCSF Institute for Genomic Immunology is looking for a highly motivated candidate with a passion for science to help with our research.  Our lab has pioneered the application of novel genetic engineering technologies such as CRISPR to primary human immune cells (Shifrut et al., Cell 2018). These new technical abilities have furthered our lab research the genetic underpinnings of T cell biology (Schmidt and Steinhart et al., Science 2022; Schmidt and Ward et al., Nature 2023) and opened the door to novel immune therapies based on engineered human immune cells (Roth et al., Nature 2018). We now are working to expand our efforts to apply similar technologies in primary human B cells. We hope to uncover new fundamental biology about B cell function, and explore the potential of engineering B cells as immunotherapy for autoimmune diseases, chronic infection, and cancer. 

What you will do:

We are hiring a research associate (RA) to work with us on establishing the first whole-genome CRISPRi/a screens in primary human B cells.  The primary responsibilities of the RA will include isolation and culture of primary human immune cells, functional analysis of engineered cells via high throughput flow cytometry, lentiviral vector design and evaluation, single-cell RNA sequencing, and CRISPR gene editing, among others. This position represents an excellent opportunity to gain exposure to basic laboratory skills, early phase clinical translation, as well as exposure to the frontier of cancer immunology and next generation genomics technologies in a dynamic, well-established research environment.

What you will need:

• BA/BS degree and one or more years of laboratory experience utilizing techniques or methods required by the position; or an equivalent combination of education and experience;
• Experience with general laboratory techniques, especially basic molecular and cellular biology techniques (including but not limited to DNA and RNA isolation, PCR, gel electrophoresis, DNA assembly, bacterial transformation, mammalian cell culture, etc.);
• Excellent organizational and interpersonal communication skills (verbal and written);
• Willingness and ability to learn new methods and skills for changing research priorities;
• Ability to work independently and as a member of a research team;
• Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines

What is preferred:

• Prior experience with culturing human cells;
• Prior experience with flow cytometry
• Prior experience with single-cell RNA-sequencing methods (e.g. 10x genomics);
• Basic proficiency in data analysis in R and/or Python

Required Application Materials:

• Resume/CV
• Cover letter with a brief statement of research background and future goals / interest in the lab
• Contact information for two references

If this role is not for you

Please stay in touch and to see a complete list of our open career opportunities, please visit:

https://gladstone.org/careers

Hiring Range:

$27.00 ($56,163) -$31.11 ($64,713.76)

Apply at: https://gladstone.wd5.myworkdayjobs.com/en-US/careers/job/San-Francisco/Research-Associate-I_REQ-3057

Research Specialist - Marson Lab

About the role:

The Marson Lab at the Gladstone-UCSF Institute for Genomic Immunology is looking for a highly motivated candidate with a passion for science to help with our research in T cell therapies for the treatment of cancer. Our lab has pioneered the application of novel genetic engineering technologies such as CRISPR to primary human immune cells (Shifrut et al., Cell 2018). These new technical abilities have furthered our lab research the genetic underpinnings of T cell biology (Schmidt and Steinhart et al., Science 2022; Schmidt and Ward et al., Nature 2023) and opened the door to novel cancer immune-therapies based on engineered human immune cells (Roth et al., Nature 2018). Our current research efforts are focused on developing and applying platforms for CRISPR-based manipulation and screening in primary human T cells to explore genetic mechanisms that regulate T cell functions and work toward therapeutic engineering of cells to treat cancer, HIV, and autoimmune diseases.

What you will do:

We are hiring a research associate (RA) to work on a project focusing on advancing pools of CRISPR modified T cells to a clinical trial for cancer patients. The primary responsibilities of the RA will include isolation and culture of primary human immune cells, functional analysis of engineered cells via high throughput flow cytometry, lentiviral vector design and evaluation, single-cell RNA sequencing, and CRISPR gene editing, among others. The RA will work with a multidisciplinary and cross-institutional team to perform groundwork experiments for advancing this cell therapy to clinical trial. This position represents an excellent opportunity to gain exposure to basic laboratory skills, early phase clinical translation, as well as exposure to the frontier of cancer immunology and next generation genomics technologies in a dynamic, well-established research environment.

What you will need:

• BA/BS degree and one or more years of laboratory experience utilizing techniques or methods required by the position; or an equivalent combination of education and experience
• Experience with general laboratory techniques, especially basic molecular and cellular biology techniques (including but not limited to DNA and RNA isolation, PCR, gel electrophoresis, DNA assembly, bacterial transformation, mammalian cell culture, etc.)
• Excellent organizational and interpersonal communication skills (verbal and written)
• Willingness and ability to learn new methods and skills for changing research priorities
• Ability to work independently and as a member of a research team
• Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines

What is preferred:

• Prior experience with culturing human cells
• Prior experience with flow cytometry
• Prior experience with single-cell RNA-sequencing methods (e.g. 10x genomics)
• Basic proficiency in data analysis in R and/or Python

Required Application Materials:

• Resume/CV
• Cover letter with a brief statement of research background and future goals / interest in the lab
• Contact information for two references

Compensation is determined by the Gladstone Institutes pay scale.

Hiring Range:

$27-$31hr

Apply at: https://gladstone.wd5.myworkdayjobs.com/en-US/careers/job/San-Francisco/Research-Associate---The-Marson-Lab-at-the-Gladstone--Institute-for-Genomic-Immunology_REQ-3071

Junior/Assistant/Associate/Full Specialist - Kamber Lab

The Kamber lab (www.kamberlab.com) is seeking a Junior/Assistant/Associate/Full Specialist to join our group and contribute to new and ongoing projects. Our lab focuses on the discovery of novel molecules that govern the ability of our immune system to recognize and destroy cancer cells and which may serve as new therapeutic targets for currently untreatable cancers. In particular, we are interested in identifying genes and proteins that regulate macrophage-mediated clearance of cancer cells. We are also interested in developing innovative CRISPR-based screening approaches to enable exploration of a wider range of understudied macrophage-related phenomena. The candidate will be expected to contribute to the core research efforts in the lab, by conducting molecular and cell biological techniques, including molecular cloning, tissue culture, CRISPR-mediated gene editing, automated live-cell imaging, flow cytometry, and next-generation sequencing. An exceptional candidate will design their own experiments, lead their own independent project, develop new ideas, be familiar with the literature, present at lab meetings, and participate in procurement of funds, where appropriate. Additionally, the specialist will be expected to assist with managing day-to-day lab operations, and perform general lab duties and be a positive lab citizen.

Required Qualifications:

• Excellent organizational and interpersonal communication skills (verbal and written)
• Willingness and ability to learn new methods and skills for changing research priorities.
• Ability to work independently and as a member of a research team.
• Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.
• Must have (or be in process of obtaining) a bachelor’s degree (or equivalent degree) or four years of research experience to be appointed at the Junior rank.
• Must have (or be in process of obtaining) a master’s degree (or equivalent degree) or a bachelor’s degree with three or more years of research experience to be appointed at the Assistant rank.
• Must have (or be in process of obtaining) a master’s degree (or equivalent degree) or five to ten years of research experience to be appointed at the Associate rank.
• Must have (or be in process of obtaining) a terminal degree (or equivalent degree) or at least ten or more years of research experience to be appointed at the Full rank.

Preferred Qualifications:

• Prior experience in the design and assembly of DNA constructs
• Prior experience in mammalian cell culture and genome manipulation (i.e. gene knockouts) and high throughput sequencing

We are seeking at least a 1-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available. This position offers the opportunity for close mentorship in a supportive and friendly environment, as well as guidance and support in achieving their long-term career goals (including training in oral and written communication, flexible scheduling to accommodate preparation for graduate/medical school examinations and interviews, and opportunities for networking with other scientists).

Applicants are strongly encouraged to submit a cover letter with their application, describing their past research experiences, research interests, career goals, and the length of time they intend to commit to the position (e.g. 1 years, 2 years, or more).

Applicants must meet requirements by the time of appointment.

Please apply online at https://aprecruit.ucsf.edu/JPF05182

See Table 24B for the salary range for this position. A reasonable estimate for this position is $53,100-$188,200.

Junior Specialist – Krummel Lab

Involves a hybrid of computational, data analytics, and systems immunology specialization with emphasis of the former two. Working at the junction of the three of these to learn basic principles of the immune system. Incumbent will apply computational, computer science, data science to perform research and to drive hypotheses for subsequent analysis in the lab. Responsibilities include research, design, development, analysis, operation, and support of data science research, software, tools and hardware resources. The incumbent will work closely with immunologists to develop data algorithms and perform computation, statistical analyses, and interpretation and reporting of research. Works and can listen and talk to biologists as well as those with various computational expertise.

Required Qualifications:

• Specialists appointed at the junior rank must possess a baccalaureate degree (or equivalent degree) or at least four years of relevant research experience by the time of hire.
• Applicants’ materials must list current and/or pending qualifications upon submission.
• Intermediate knowledge of data science tools including facility with Python and R.
• Proven skills and experience in independently resolving broad computing / data science problems using introductory and / or intermediate principles.

Preferred Qualifications:

• Demonstrated broad experience in one or more of the following: matrix factorization methods and knowledge networks.

Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service. Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary and rank will be commensurate with the applicants experience and training.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300 - $54,600.

Please apply online at https://aprecruit.ucsf.edu/JPF04990.

Junior or Assistant Research Specialist - Fassett Lab

The Fassett laboratory at the UCSF-Parnassus Campus is looking for a dedicated and enthusiastic recent college graduate to join our team as a junior/asst research specialist. Founded in spring 2023, our growing research group studies T cell biology and allergic inflammation in skin, lungs, and gut. Your direct supervisor will be Dr. Marlys Fassett, a physician-scientist/dermatologist whose research program spans from in vitro molecular immunology to neuroimmunology to mouse models of inflammatory disease.

Required: The ideal candidate will have completed relevant coursework in neuroscience, immunology or molecular biology

Preferred: hands-on research experience in immunology

Key experimental techniques you will be expected to learn and perform with us include: mouse and human tissue processing, flow cytometry, mouse husbandry, and other animal procedures. Up to 10% of your time will also be dedicated to general lab support such as ordering and receiving of supplies. We also intend to support you as you develop sufficient skills and autonomy to drive an independent research sub-project within the lab. Depending upon your prior experience and interest, your project may involve experiments that employ immunofluorescence microscopy, analysis of RNA-sequencing data, or development of novel assays to model the relationship between sensory nerves and other skin cell types in vitro.

The Position: Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions and may participate in University and Public Service. Specialists appointed at the junior rank must possess a baccalaureate degree (or equivalent degree) or equivalent research experience (e.g., with instrumentation and research equipment, social science research methods, or creative activities). Specialists appointed at the Assistant rank must possess a master’s degree (or equivalent degree) or a bachelor’s degree with three or more years of research experience. Preference given to candidates with hands on experience in flow cytometry, in vitro cell differentiation assays, and/or other core immunology techniques. Candidates must meet all of the required qualifications at the time of appointment. Candidate’s CV must state qualifications (or if pending) upon submission.

Timing: Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary and rank will be commensurate with the applicants experience and training. The anticipated start date on is on or before [date].

Contact: To be considered for the position you must also apply online at https://aprecruit.ucsf.edu/JPF04896, with a CV and the contact information of three references.

Junior or Assistant Specialist - Ricardo-Gonzalez Lab

Department of Dermatology

Job Description
The Ricardo-Gonzalez Lab (rrglab.com) is a recently established immunology laboratory interested in understanding how tissue-resident immune cells influence tissue physiology and function. The research specialist will perform basic and translational research to investigate the role of innate and adaptive immune cells in tissue homeostasis and models of infection, inflammation, and cancer. We seek a specialist who will assist the team by performing laboratory and investigative procedures using a wide array of experimental techniques such as flow cytometry, immunofluorescence imaging, PCR, cell culture (cell lines and primary cells), plasmid prep and purification, molecular cloning, and ELISA-like assays. Translational research components will involve experiments with human blood and tissue samples. Specialist responsibilities regarding mouse model systems will include breeding, screening, and immunizing mice as well as dissecting tissues to obtain cells for culture and analysis of gene expression.

Required Qualifications:

• Excellent organizational skills
• Willingness and ability to learn new methods and skills as needed for changing research priorities.
• Ability to work independently and as a member of a research team.
• Must be organized and have the ability to prioritize tasks, coordinate work tasks with others, and manage to meet multiple deadlines.
• Ability to maintain a comprehensive laboratory notebook of experiments done on a daily basis.
• Demonstration of accuracy and attention to detail in sample preparation during prior research experience is required.
• Excellent interpersonal communication, ability to consent and recruit patients for the studies.
• Ability to use or learn to enter information into REDCap database.
• Specialist appointed at the Junior rank must possess (or be in process of obtaining) a bachelor’s degree (or equivalent degree) in biology, biochemistry, or a related scientific discipline or four years of research experience.
• Specialists appointed at the Assistant rank must possess (or be in process of obtaining) a master’s degree (or equivalent degree) in biology, biochemistry, or a related scientific discipline or a bachelor’s degree in biology, biochemistry, or a related scientific discipline with three or more years of research experience.
• Candidates must meet the requirements by the time of appointment.

Preferred Qualifications:

• Experience with mouse models of human disease
• Experience with cell culture and sterile technique
• Experience with infectious disease models in mice
• Computational biology coursework and/or research experience
• Flow Cytometry (FACS): Ability to perform multicolor flow cytometry.
• Transgenic Mouse Work: Experience with experimental animal research. Comfort with handling, manipulating, euthanizing, and dissecting experimental animals.
• Fluorescence Microscopy: Experience with sample preparation, immunofluorescence staining, and use of epifluorescence and confocal microscopes for image acquisition.
• Communication, logistical, and time management skills to coordinate work with other lab members.

Licensure/Certification/Registration: None required.

Physical Requirements:

• Good visual acuity and accurate color discrimination.
• The position requires excellent manual dexterity and familiarity utilizing delicate instrumentation.
• Occasionally lifts and/or carries objects weighing up to 20 pounds.
• Work involves possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances.
• Long periods of standing and/or sitting.

Please apply online at https://aprecruit.ucsf.edu/JPF04888, and submit a CV, cover letter and 3 reference contacts.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$65,900.

Junior Specialist – Turnbaugh Lab

The Turnbaugh lab is seeking a Junior Specialist to join our group and contribute to new and ongoing projects. This work will focus on the study of the microbiome using Gnotobiotic mice, and will include performing advanced experimental techniques to execute experiments (for example, the Specialist may administer experimental agents via oral, i.p., or subcutaneous routes, and follow up with experimental disease scoring and tracking, dissection and processing of tissues, or other techniques deemed experimentally necessary). Lab techniques performed by the Specialist include (but are not limited to): DNA extraction, PCR, qPCR, microbial cultures, gram staining, and genotyping. The candidate will also be expected to contribute to novel projects advancing research and development of Gnotobiotic tools. For example, the candidate will work on the development of novel models (such as allergy and asthma) in sterile mice and the translation of embryo-transfer techniques into a germ-free setting, among other projects. An exceptional candidate will move these projects forward independently, helping the lab to develop and test new ideas. Additionally, the specialist will be expected to assist with managing day-to-day lab operations within the Gnotobiotic core facility, perform general lab duties, and be a positive lab citizen.

Required Qualifications:
• Excellent organizational and interpersonal communication skills (verbal and written)
• Willingness and ability to learn new methods and skills for changing research priorities.
• Ability to work independently and as a member of a research team.
• Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.
• Must have (or be in process of obtaining) a bachelor’s degree (or equivalent degree) or at least four years of research experience to be appointed at the Junior rank.

Preferred Qualifications:
• Prior experience with handling pathogenic microbes, aseptic techniques
• Prior experience working in a research-based setting with murine models
• Prior experience in gnotobiotic mouse handling/maintenance in positive pressure isolators, with a focus on sterility
• Prior experience in advanced techniques in murine models (such as injection of compounds, oral gavage, anesthesia, surgery techniques and documentation)

We are seeking at least a 1-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available.

Applicants must meet requirements by the time of appointment.

Please apply online at https://aprecruit.ucsf.edu/JPF04892

Junior Specialist or Assistant Specialist positions are now open for the Clelland Lab at the UCSF Weill Institute for Neurosciences. The goal of the Clelland lab is develop novel therapies for neurodegenerative diseases like dementias and ALS. Projects focused on basic mechanisms of disease and CRISPR gene editing in iPSC-derived neurons. We work with our close collaborators at the Innovative Genomics Institute. Applicants intending on progressing to graduate or medical school are encouraged to apply.

Required Qualifications:

• Junior Specialist- A Bachelor’s degree or at least 4 years of research experience required by start date.
• Assistant Specialist- A Master’s degree or a Bachelor’s degree with 3 or more years of research experience by the start date.
• Laboratory experience
• A background in molecular biology or bioinformatics
• Strong communication skills

Preferred Qualifications:

• A college degree
• Cell culture experience

Start dates flexible until the position is filled. We prefer a 2-year commitment.

Please apply online at https://aprecruit.ucsf.edu/JPF04993, with a resume (CV), unofficial transcript, cover letter, and two references.

For other inquiries, please contact Jaime Mohl at [email protected].

Salary competitive and commensurate with experience.
See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$65,900.