UCSF’s innovative, collaborative approach to patient care, research and education spans disciplines across the life sciences, making it a world leader in scientific discovery and its translation to improving health.

Odessa Yabut, PhD

ASST ADJ PROF-HCOMP

M_Neurology

[email protected]

+1 415 514-4949

Dr. Yabut's primary research interest is to elucidate the molecular mechanisms regulating neural stem cell behavior in stem cell niches of the developing and postnatal brain using rational mouse models. The ultimate goal of Dr. Yabut's research program is to advance our knowledge on how distinct and functional neural cell lineages are produced and facilitate the development of diagnostic and therapeutic tools to treat neurodevelopmental and neuro-oncological diseases.

Publications

Suppressor of Fused regulates the proliferation of postnatal neural stem and precursor cells via a Gli3-dependent mechanism.

Biology open

Gomez HG, Noguchi H, Castillo JG, Aguilar D, Pleasure SJ, Yabut OR

Sonic Hedgehog Signaling Rises to the Surface: Emerging Roles in Neocortical Development.

Brain plasticity (Amsterdam, Netherlands)

Yabut OR, Pleasure SJ

The Dorsal Wave of Neocortical Oligodendrogenesis Begins Embryonically and Requires Multiple Sources of Sonic Hedgehog.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Winkler CC, Yabut OR, Fregoso SP, Gomez HG, Dwyer BE, Pleasure SJ, Franco SJ

The Crossroads of Neural Stem Cell Development and Tumorigenesis.

Opera medica et physiologica

Yabut OR, Pleasure SJ

Loss of Suppressor of Fused in Mid-Corticogenesis Leads to the Expansion of Intermediate Progenitors.

Journal of developmental biology

Yabut OR, Ng HX, Fernandez G, Yoon K, Kuhn J, Pleasure SJ

Suppressor of Fused Is Critical for Maintenance of Neuronal Progenitor Identity during Corticogenesis.

Cell reports

Yabut OR, Fernandez G, Huynh T, Yoon K, Pleasure SJ

A Notch above Sonic Hedgehog.

Developmental cell

Yabut O, Pleasure SJ, Yoon K

The quintessence of quiescence.

Neuron

Yabut O, Pleasure SJ

miR-125b promotes early germ layer specification through Lin28/let-7d and preferential differentiation of mesoderm in human embryonic stem cells.

PloS one

Wong SS, Ritner C, Ramachandran S, Aurigui J, Pitt C, Chandra P, Ling VB, Yabut O, Bernstein HS

The promise of human embryonic stem cells in aging-associated diseases.

Aging

Yabut O, Bernstein HS

Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Zhang J, Li H, Yabut O, Fitzpatrick H, D'Arcangelo G, Herrup K

Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Yabut O, Domogauer J, D'Arcangelo G

The Reelin signaling pathway promotes dendritic spine development in hippocampal neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Niu S, Yabut O, D'Arcangelo G

Abnormal laminar position and dendrite development of interneurons in the reeler forebrain.

Brain research

Yabut O, Renfro A, Niu S, Swann JW, Marín O, D'Arcangelo G