Job Opportunities

Junior/Assistant/Associate/Full Specialist - Larson Lab

The Larson Lab is seeking a Junior, Assistant, Associate, or Full Specialist. This position is focused on using modern machine learning and computer vision algorithms for automated large-scale analyses of cancer imaging data, working with Dr. Thomas Hope (https://profiles.ucsf.edu/thomas.hope) and Prof. Peder Larson (http://www.radiology.ucsf.edu/research/labs/larson).

More specifically, positron emission tomography (PET) with prostate-specific membrane antigen (PSMA) based agents is transforming the assessment of lethal advanced prostate cancers. UCSF and Dr. Thomas Hope have led the clinical translation of this agent, and a key next step is to develop advanced tools for analyzing PSMA PET data. This promises to maximize the utility by improving our understanding how the measurements in PSMA PET images in relation to diseases progression and treatments.

We propose to develop such advanced analysis tools using modern machine learning and computer vision methods to automatically segment and classify lesions as well as provide quantitative measures of localized disease burden.

The responsibilities of this position include:

Curation and management of cancer imaging datasets
Integration of information from clinical databases and clinicians
Training machine learning models using cancer imaging datasets

Required Qualifications:

Specialists appointed at the Junior rank must possess a baccalaureate degree in Computer Science, Electrical Engineering, Data Science, (or equivalent degree or related field) or at least four years of research experience.
Specialists appointed at the Assistant rank must possess a master’s degree (or equivalent degree) or a baccalaureate degree with three or more years of research experience.
Specialists appointed at the Associate rank must possess a master’s degree (or equivalent degree) or five to ten years of research experience.
Specialists appointed at the Full rank must possess a terminal degree (or equivalent degree) or ten or more years of research experience.
Must have strong written and verbal communication skills.
Ability to work on collaborative research projects in a multi-disciplinary team.
Applicants must meet all of the requirements by the time of hire.
Applicant materials must list current and/or pending qualifications upon submission.

Preferred Qualifications:

Experience with Python and PyTorch
Setting up and curating large datasets
Computer vision model development
Training of Machine Learning models
Training of Machine Learning models based on image data

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$181,800.

Please apply online at: https://aprecruit.ucsf.edu/JPF05026 with a cover letter, CV, and contact information for two references.

Junior Specialist – Krummel Lab

Involves a hybrid of computational, data analytics, and systems immunology specialization with emphasis of the former two. Working at the junction of the three of these to learn basic principles of the immune system. Incumbent will apply computational, computer science, data science to perform research and to drive hypotheses for subsequent analysis in the lab. Responsibilities include research, design, development, analysis, operation, and support of data science research, software, tools and hardware resources. The incumbent will work closely with immunologists to develop data algorithms and perform computation, statistical analyses, and interpretation and reporting of research. Works and can listen and talk to biologists as well as those with various computational expertise.

Required Qualifications:

Specialists appointed at the junior rank must possess a baccalaureate degree (or equivalent degree) or at least four years of relevant research experience by the time of hire.
Applicants’ materials must list current and/or pending qualifications upon submission.
Intermediate knowledge of data science tools including facility with Python and R.
Proven skills and experience in independently resolving broad computing / data science problems using introductory and / or intermediate principles.

Preferred Qualifications:

Demonstrated broad experience in one or more of the following: matrix factorization methods and knowledge networks.

Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service. Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary and rank will be commensurate with the applicants experience and training.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300 - $54,600.

Please apply online at https://aprecruit.ucsf.edu/JPF04990.

Junior, Assistant, or Associate Specialist - Collins Lab

The Department of Orthopaedic Surgery is seeking a Non-Faculty Academic Junior, Assistant, or Associate Specialist position in the Department of Orthopaedic Surgery, Laboratory for Musculoskeletal Crosstalk run by Dr. Kelsey Collins.

In the Collins lab, we leverage interdisciplinary approaches in bioengineering, endocrinology, and physiology to determine molecular mechanisms of tissue crosstalk in osteoarthritis. The incumbent will be responsible for supporting the molecular, cellular, and tissue biology activities of the laboratory by participating in induced pluripotent stem cell culture, editing of cell lines, histology, animal husbandry and others. They will also independently perform more complex biological analyses using new and established approaches, and support the development of new protocols and application of spatial transcriptomic and proteomic analyses to musculoskeletal and adipose tissues. The position requires someone who can contribute to an independent project while working in a team-based environment. The incumbant will participate in animal handling, record keeping, data management, communication with laboratory and Laboratory Animal Resource Center (LARC) staff, molecular analyses of genotype, and data interpretation.

In the Laboratory for Musculoskeletal Crosstalk, we value diversity in backgrounds and experience. We believe that diversity drives creativity and innovation, and we are dedicated to fostering an inclusive ecosystem where everyone feels valued and respected. Join us and be part of our mission to improve patient outcomes through exciting and innovative approaches in Orthopaedic Research.

Required Qualifications:
• Specialists appointed at the junior rank must possess (or in the process of obtaining) a baccalaureate degree (or equivalent degree) in bioengineering, stem cell or molecular biology, immunology or a related field or at least four years of research experience.
• Specialists appointed at the Assistant rank must possess (or in the process of obtaining) a master’s degree in bioengineering, stem cell or molecular biology, immunology or a related field or a baccalaureate degree with 3 or more years of research experience.
• Specialists appointed at the Associate rank must possess (or in the process of obtaining) a master’s degree in bioengineering, stem cell or molecular biology, immunology or a related field) or five to ten years of experience in the relevant specialization.
• Applicants must have obtained the degree requirement for the Specialist rank by the time of hire.
• Robust Molecular biology skills.
• Cell culture expertise.
• Primary cell culture experience.
• Demonstrated excellent verbal, written and communication skills.
• Strong skills in attention to detail.
• Analytical and judgment skills to conduct analyses and develop appropriate recommendations.
• A collaborative spirit and are comfortable with working in teams.
• Applicants’ materials must list current and/or pending qualifications upon submission.

Preferred Qualifications:
• Interest in or experience with using mouse models or stem cells preferred.
• Histology and immunohistochemistry experience, orthopaedic research experience preferred.
• Coursework in statistics preferred.
• Interest in conducting pain and behavioral testing on rodents is a plus.

Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary and rank will be commensurate with the applicants experience and training.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $49,000 - $78,500.

Please apply online at https://aprecruit.ucsf.edu/JPF04529.

Junior or Assistant Specialist - Clelland Lab

Junior Specialist or Assistant Specialist positions are now open for the Clelland Lab at the UCSF Weill Institute for Neurosciences. The goal of the Clelland lab is develop novel therapies for neurodegenerative diseases like dementias and ALS. Projects focused on basic mechanisms of disease and CRISPR gene editing in iPSC-derived neurons. We work with our close collaborators at the Innovative Genomics Institute. Applicants intending on progressing to graduate or medical school are encouraged to apply.

Required Qualifications:

Junior Specialist- A Bachelor’s degree or at least 4 years of research experience required by start date.
Assistant Specialist- A Master’s degree or a Bachelor’s degree with 3 or more years of research experience by the start date.
Laboratory experience
A background in molecular biology or bioinformatics
Strong communication skills

Preferred Qualifications:

A college degree
Cell culture experience

Start dates flexible until the position is filled. We prefer a 2-year commitment.

Please apply online at https://aprecruit.ucsf.edu/JPF04993, with a resume (CV), unofficial transcript, cover letter, and two references.

For other inquiries, please contact Jaime Mohl at [email protected].

Salary competitive and commensurate with experience.
See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$65,900.

Junior/Assistant/Associate Specialist - Liao Lab

The Department of Dermatology is seeking a Junior, Assistant or Associate Specialist in the Liao Lab. We are an experimental and computational genomics laboratory that studies how the skin and immune system functions in human tissues. The position will consist of bioinformatics analysis and wet lab experiments. This individual will be responsible for applying bioinformatic and machine learning techniques to genomic data, which will generated through RNA-seq, proteomics, and spatial-seq experiments.

Appointees in the Specialist series will be expected to engage in specialized professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service.

Specialists appointed at the junior rank must possess a baccalaureate degree (or equivalent degree) or at least four years of equivalent research experience (e.g., with instrumentation and research equipment, social science research methods, or creative activities). Specialists appointed at the Assistant rank must possess a master’s degree (or equivalent degree) or a bachelor’s degree with three or more years of research experience. Specialists appointed at the Associate rank must possess a master’s degree (or equivalent degree) or five to ten years of relevant experience.

A 12-month commitment to working in the lab is also required, but the position is open for longer term employment. Candidates must meet all required qualifications at the time of appointment. Candidate's CV must state basic qualifications (or if pending) upon submission.
Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary and rank will be commensurate with the applicants experience and training.

Please apply online at https://aprecruit.ucsf.edu/JPF04979 with a CV and three references.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$82,100.

Junior or Assistant Research Specialist - Fassett Lab

The Fassett laboratory at the UCSF-Parnassus Campus is looking for a dedicated and enthusiastic recent college graduate to join our team as a junior/asst research specialist. Founded in spring 2023, our growing research group studies T cell biology and allergic inflammation in skin, lungs, and gut. Your direct supervisor will be Dr. Marlys Fassett, a physician-scientist/dermatologist whose research program spans from in vitro molecular immunology to neuroimmunology to mouse models of inflammatory disease.

Required: The ideal candidate will have completed relevant coursework in neuroscience, immunology or molecular biology

Preferred: hands-on research experience in immunology

Key experimental techniques you will be expected to learn and perform with us include: mouse and human tissue processing, flow cytometry, mouse husbandry, and other animal procedures. Up to 10% of your time will also be dedicated to general lab support such as ordering and receiving of supplies. We also intend to support you as you develop sufficient skills and autonomy to drive an independent research sub-project within the lab. Depending upon your prior experience and interest, your project may involve experiments that employ immunofluorescence microscopy, analysis of RNA-sequencing data, or development of novel assays to model the relationship between sensory nerves and other skin cell types in vitro.

The Position: Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions and may participate in University and Public Service. Specialists appointed at the junior rank must possess a baccalaureate degree (or equivalent degree) or equivalent research experience (e.g., with instrumentation and research equipment, social science research methods, or creative activities). Specialists appointed at the Assistant rank must possess a master’s degree (or equivalent degree) or a bachelor’s degree with three or more years of research experience. Preference given to candidates with hands on experience in flow cytometry, in vitro cell differentiation assays, and/or other core immunology techniques. Candidates must meet all of the required qualifications at the time of appointment. Candidate’s CV must state qualifications (or if pending) upon submission.

Timing: Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary and rank will be commensurate with the applicants experience and training. The anticipated start date on is on or before [date].

Contact: To be considered for the position you must also apply online at https://aprecruit.ucsf.edu/JPF04896, with a CV and the contact information of three references.

Junior/Assistant/Associate/Full Specialist - Kriegstein Lab

The Kriegstein lab is seeking a Junior/Assistant/Associate/Full Specialist to join our group and contribute to new and ongoing projects. Our lab focuses on studies of human bain development using postmortem tissue samples and in vitro organoid models. We are also doing single cell RNAsequencing and ATACsequencing of developing human and non-human primate brain and spatial transcriptomics. The candidate will be expected to contribute to these projects, help with experimental design, tissue culture, and data analysis. An exceptional candidate will lead their own independent project, develop new ideas, be familiar with the literature, and participate in procurement of funds, where appropriate. Additionally, the specialist will be expected to assist with managing day-to-day lab operations, and perform general lab duties and be a positive lab citizen.

Required Qualifications:
• Excellent organizational and interpersonal communication skills (verbal and written)
• Willingness and ability to learn new methods and skills for changing research priorities.
• Ability to work independently and as a member of a research team.
• Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.
• Must have (or be in process of obtaining) a bachelor’s degree (or equivalent degree) or four years of research experience to be appointed at the Junior rank.
• Must have (or be in process of obtaining) a master’s degree (or equivalent degree) or at least five to ten years of research experience to be appointed at the Assistant or Associate ranks.
• Must have (or be in process of obtaining) a terminal degree (or equivalent degree) or at least ten or more years of research experience to be appointed at the Full rank.

Preferred Qualifications:
• Prior experience with tissue culture techniques.
• Prior experience in microscopy and immunohistochemistry.
• Prior experience in pluripotent stem cell differentiation.

We are seeking at least a 1-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available.

Applicants must meet requirements by the time of appointment.

Please apply online at https://aprecruit.ucsf.edu/JPF04410. Applicants’ materials must list current and/or pending qualifications upon submission.

See Table 24B (https://www.ucop.edu/academic-personnel-programs/_files/2022-23/july-2022-salary-scales/t24-b.pdf) for the salary range for this position. A reasonable estimate for this position is $49,000-$173,900.

Junior Specialist - Huang Lab

The Huang Lab in the Cardiovascular Research Institute at University of California, San Francisco is seeking a Junior Specialist. The candidate will be responsible for designing experiments, analyzing cardiomyocyte proliferation and regeneration, and gene function tests using adenoviral vectors.

Specialists appointed at the junior rank must possess a baccalaureate degree (or equivalent degree) or at least four years of research experience (e.g., with instrumentation and research equipment, social science research methods, or creative activities).

Please apply online at https://aprecruit.ucsf.edu/JPF05003, with a CV and Cover Letter (include your career plan and a link to the LinkedIn profile, if available).

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300 - $54,600.

Junior Specialist - Bose Lab

The lab of Rohit Bose MD PhD at UCSF ( http://boselab.bio ) is searching for exceptionally motivated and enthusiastic research specialists. The lab is run by a practicing physician-scientist focused on understanding how tumors evolve under different therapeutic and environments. The lab focuses on using clinically relevant immunocompetent cancer models to develop & test novel therapeutic strategies. Although primarily a lab-focused position, the candidate will also interface with clinical teams regarding patient data & samples. The specialist will be an integral member of the research team. Thus, the position will require a degree of independence but is still under general supervision. This type of experience is superb preparation for application to graduate or medical school. The position is a balancing act and requires an organized person with talent for multi-tasking, as there are three key components:

Is expected to help in the day-to-day running and operation of the lab itself
Collaborate with other members on research projects
exceptional candidates will lead their own independent project(s), develop new ideas, be familiar with the literature, and participate in procurement of funds, where appropriate.

Required Qualifications:

Must have (or be in process of obtaining) a bachelor’s degree (or equivalent degree) or four years of research experience to be appointed at the Junior rank.
Must possess a master’s degree or a baccalaureate degree with three or more years of research experience to be appointed at the Assistant.
Must have (or be in process of obtaining) a master’s degree (or equivalent degree) or five to ten years of research experience to be appointed at the Associate rank.
Must have (or be in process of obtaining) a terminal degree (or equivalent degree) or at least ten or more years of research experience to be appointed at the Full rank.
Willingness and ability to learn new methods and skills for changing research priorities.
Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.
Ability to perform repetitive tasks routinely and precisely (plating cells, running samples, etc).
Flexibility to work occasionally on weekends.

Preferred Qualifications:

Prior lab experience from academic or industry (beyond coursework).
Familiarity with any of the following: mammalian cell culture, flow cytometry, microscopy, immunostating, immunofluorescence, molecular biology, use of mouse models.
Candidates interested in applying to graduate or medical school are encouraged to apply.

We are seeking at least a 1-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available.

Applicants must meet requirements by the time of appointment.

Please apply online at https://aprecruit.ucsf.edu/JPF04721, with a CV and 2 references (contact information only). A cover letter is recommended but not required.

Junior Specialist - Knox Lab

The Knox Lab is seeking a Junior Specialist to join the group and contribute to new and ongoing research focused on dry eye disease and nerve-tissue interactions in the cornea. Using an autoimmune disease mouse as our model system, we study the cellular and molecular basis of dry eye and the mechanisms of chronic injury and cornea regeneration. The candidate will be expected to contribute to these research directions, by using techniques including mouse genetics, molecular biology, immunohistochemistry, 3D imaging, bioinformatics, etc. An exception candidate will lead their own independent project, be familiar with the literature, develop new ideas, and participate in procurement of funds, where appropriate. Additionally, the Junior Specialist will be expected to assist with managing day-to-day operations, and perform general lab duties and be a positive lab citizen. Depending on performance and workload, mentorship of other trainees, and scientific writing will be available.

Required Qualifications:

Must have (or be in process of obtaining) a baccalaureate degree (or equivalent degree) or at least four years of research experience to be appointed at the Junior rank.
Excellent organizational and interpersonal communication skills (verbal and written).
Willingness and ability to learn new methods and skills for changing research priorities.
Ability to work independently and as a member of a research team.
Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.

We are seeking an 18-month to 2-year commitment. We are committed to fostering a diverse, equitable, and inclusive workplace in our lab, and welcome applicants from underrepresented backgrounds to join us.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$54,600.

Please apply online at https://aprecruit.ucsf.edu/JPF05007 with CV and contact information for two references. Applicant materials must list current and/or pending qualifications upon submission. The selected candidate must meet all of the qualifications at the time of appointment.

Junior Specialist - Hutchins Lab

The Hutchins lab at UCSF (www.devbiorna.com) is seeking a Junior Specialist to work on post-transcriptional regulation in the developing chicken embryo. The selected candidate will conduct research under the guidance of Dr. Hutchins and members of the Hutchins Lab. The Junior Specialist will learn and utilize a variety of research techniques and have the opportunity to be a co-author on publications. This is a great opportunity for anyone interested in pursuing a biomedical sciences PhD or MD.

Job responsibilities include but are not limited to:

Chick embryo dissection, electroporation of expression constructs, knockdown reagents, tissue processing with Hybridization Chain Reaction (HCR) and immunostaining in whole mount and frozen tissue sections.
Molecular biology assays including basic cloning, plasmid preparation, RNA extraction.
Maintaining lab reagent stocks, preparing chemical solutions.

Required Qualifications:

Specialists appointed at the Junior rank must possess a bachelor’s degree (or equivalent degree) or at least four years of research experience.
Demonstrated ability to learn new techniques and think critically about experiments.
Experience in or ability to prepare chemical solutions and manage lab reagent inventory.
Demonstrated ability to perform basic mathematical calculations related to preparing solutions from concentrated lab stocks, calculating molarity, etc.
Applicants need to be organized and self-motivated and enthusiastic about science and medicine.
Excellent verbal and written communication skills.

Preferred Qualifications:

Experience in performing PCR, gel electrophoresis, plasmid purification, and cloning is preferred.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$54,600.

Please apply online at: https://aprecruit.ucsf.edu/JPF05070 with a cover letter, CV, statement of contributions to diversity, and contact information for three references. Applicant materials must list current and/or pending qualifications upon submission. The selected candidate must meet all of the qualifications at the time of appointment.

Junior Specialist - Guo Lab

A junior specialist position is available in the brain science laboratory, UCSF Bioengineering and Therapeutic Sciences Department. We are interested in understanding the basic and disease-associated processes involved in brain development, maintenance, and function, in the context of developmental, neurodegenerative, and neuropsychiatric disorders. For more info about the lab, see https://pharm.ucsf.edu/guo

We strongly encourage candidates from diverse and under-represented backgrounds to apply.

Training/learning opportunities and responsibilities include the following:

Work with postdoctoral fellows and graduate students to gain both problem-solving and technical skills in molecular biology, cell biology, genetics, pharmacology, behaviour, and data analysis.
Engage in other lab duties (e.g. ordering lab reagents and supplies, protocol submission, lab stock maintenance, database entry/maintenance) as assigned.

Requirements:

BA/BS degree in Biological Sciences, Neuroscience, chemistry, or other related fields
Have proven ability to work well as part of a team
Enthusiastic about the practice of science and plan to obtain PhD, MD/PhD, or MD after this position
A minimum of 2-year commitment to the position

Please apply online at https://aprecruit.ucsf.edu/JPF04608, with a CV, cover letter and three reference contacts.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $49,000-$52,200.

Junior Specialist - Fraser Lab

The Department of Bioengineering and Therapeutic Sciences is now recruiting a Junior Specialist. The area of specialization and responsibilities will include the following:

The candidate will mainly be involved in collaborative projects involving X-ray crystallography (including fragment-based screening). This implies protein crystallization and optimization, data collection at the beamline, data processing and 3D structure solving.
The candidate will crystallize protein-ligand complexes, deliver high quality X-ray co-crystal structures, and provide structural insights for the design of small molecule therapeutics
The candidate will handle on an occasional basis, the day-to-day operations of the X-ray crystallography facility, which houses automated equipment such as mosquito and dragonfly crystallization robots, Formulatrix Imaging robots, Nanuq and Shifter…
The candidate will maintain and safely operate the facility’s equipment, by making sure the instruments are always well calibrated and ready-to-use.
The candidate will be responsible for the facility’s consumables stock and order supplies as needed.
The candidate will interact with users (faculty, staff, students) and train them to make sure they are independent in using the facility's equipment. The candidate will also provide technical support during the use of equipment if needed, after training.

Required Qualifications:

A bachelor’s degree ( or equivalent degree) or at least four years of research experience.
Experience with protein expression and purification
Strong understanding of protein structure and protein-ligand interactions
Candidates must meet the required qualifications at the time of appointment.
Candidate's CV must state required qualifications (or if pending) upon submission.

Preferred Qualifications:

Experience with crystallization robotics and optimizing crystallization conditions.
Experience with protein crystal harvesting and data collection.
Experience with common crystallographic and visualization software packages

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$54,600.

Please apply online at https://aprecruit.ucsf.edu/JPF04712 with a CV, cover letter, and three references.

Junior/Assistant/Associate/Full Specialist - Flavell Lab

The Flavell lab is seeking a Junior, Assistant, Associate, or Full Specialist.

The Specialist will focus on the development of novel molecular imaging and theranostic probes for imaging and treatment of cancer. We have active projects on the development of antibody, nanoparticle, and small molecule based-theranostic agents for imaging and treatment of prostate cancer, multiple myeloma, and other diseases. Projects span from initial synthesis to preclinical validation, to translational studies.

Required Qualifications:

Specialists appointed at the Junior rank must possess a bachelor’s degree (or equivalent degree) or at least four years of research experience.
Specialists appointed at the Assistant rank must possess a master’s degree (or equivalent degree) or a bachelor’s degree with three or more years of research experience.
Specialists appointed at the Associate rank must possess a master’s degree (or equivalent degree) or five to ten years of research experience.
Specialists appointed at the Full rank must possess a terminal degree (or equivalent degree) or ten or more years of research experience.
Applicants must meet all the qualifications by the time of hire.
Candidate’s CV and/or cover letter must state qualifications (or if pending) upon submission.

Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary and rank will be commensurate with the applicants experience and training.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-181,800.

Please apply online at: https://aprecruit.ucsf.edu/JPF04580 with a cover letter and CV.

Junior Specialists - Piao Lab

UCSF School of Medicine and UCSF Benioff Children's Hospitals
Department of Pediatrics & Weill Institute for Neurosciences
Junior Specialists

The Piao Lab at the Weill Institute for Neurosciences of the University of California, San Francisco is actively seeking multiple Junior Specialists. We invite highly motivated, independent, and organized individuals to join our team. As part of our collaborative environment, you will contribute to the study of neuroimmune interplays and their impact on typical brain development, homeostasis, and their role in neurodevelopmental and neurodegenerative diseases.

Selected candidates will join a major academic medical center and established training program. This position would actively contribute to the Department's mission of excellence in research, education, and patient care.

Key Responsibilities:

Participate in ongoing studies of mouse models:
- Work with laboratory animals (e.g., rodents).
- Involvement in maintaining transgenic mouse colonies and performing essential procedures.
Conduct independent research under guidance:
- Pursue independent research projects within the scope of glial-glial and glial-neuronal interactions in brain development and diseases.
Write and edit manuscripts:
- Co-author original research articles, review papers, and book chapters.
- Edit manuscripts and assist in crafting grant applications.
Perform administrative tasks:
- Share administrative duties with other SRAs in the lab.
- Gain experience in routine lab management, including ordering, equipment maintenance, and writing and managing lab protocols.

Required Qualifications:

Specialists appointed at the Junior rank must possess a baccalaureate degree (or equivalent degree) or at least four years of research experience.

Preferred Qualifications:

Ideal candidates will have knowledge of biology, neuroscience, or a related field.
Minimum two-year undergraduate wet laboratory research experience.
Meticulous recordkeeping, organizational skills, and excellent communication skills are essential.
A strong passion for science and a positive attitude are highly desirable.
Plus points for strong scientific writing skills and prior editing experience.

Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary and rank are commensurate with the applicants experience and training.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$54,600.

Interested candidates can apply online at https://aprecruit.ucsf.edu/JPF04859 with a cover letter, curriculum vitae, and contact information for 3 references. Applicant materials must list current and/or pending qualifications upon submission. The selected candidate(s) must meet all of the qualifications at the time of appointment.

Junior, Assistant, Associate, or Full Specialist - McManus Lab

The McManus lab is looking for a candidate to be open to learning new methods and must have excellent communication skills, as this position requires teamwork in a laboratory environment. The position represents an excellent opportunity for basic laboratory and research skills in a dynamic environment. The successful applicant will be an energetic, team player, self-directed learner with a keen interest in research.

Under direct supervision and with guidance from senior lab members, the employee will be expected to perform experiments to support lab members research. The specific types of experiments will vary and include assisting high throughput microscopy and the use state of the other technologies located in the PCAT (robotics, cytometry, plate reader, etc). Assist the PI in overseeing ViraCore activities. This duty will involve teaching cell culture, virus production, and related tasks to ViraCore staff members.

Required Qualifications:

Specialists appointed at the junior rank must possess (or in the process of obtaining) a baccalaureate degree (or equivalent degree) in Neuroscience, Behavior, Physiology, Biology, Molecular Biology, or a related science or at least four years of research experience.
Specialists appointed at the Assistant rank must possess (or in the process of obtaining) a master’s degree in Neuroscience, Behavior, Physiology, Biology, Molecular Biology, or a related science or a baccalaureate degree with 3 or more years of research experience.
Specialists appointed at the Associate rank must possess (or in the process of obtaining) a master’s degree (or equivalent degree) in Neuroscience, Behavior, Physiology, Biology, Molecular Biology, or a related science or five to ten years of experience in the relevant specialization.
Specialists appointed at the full rank must possess (or in the process of obtaining) a terminal degree (or equivalent degree) in Neuroscience, Behavior, Physiology, Biology, Molecular Biology, or a related science or ten or more years of experience in the relevant specialization.
Applicants must meet requirements by the time of hire.
Applicants’ materials must list current and/or pending qualifications upon submission.
Experience in basic molecular biology protocols, including PCR and qPCR (may be that which is acquired while in school).
Experience with Biomek robotics instrumentation.
Experience and/or motivation to work with small animals/mouse colony.
Experience with high content microscopy.
Expertise in cell culture and lentivirus preparation.
Knowledge/experience with basic techniques/methods required by the position; or an equivalent combination of education and experience.
Practical laboratory experience, such as benchwork in biomedical research laboratory (may include undergraduate experience.
Effective use of laboratory instruments and their maintenance; knowledge of biomedical and biotechnological techniques and methodologies.
Basic understanding of trouble-shooting experiments and problem solving.
Data analysis and interpretation skills.
Excellent verbal and written communication skills, initiative to work independently and efficiently.
Ability to trouble-shoot experiments.
Ability to analyze data in spreadsheets.
Ability to handle and prioritize responsibilities pertaining to multiple projects.

Preferred Qualifications:

Basic skills in statistical analysis and the use of relevant statistical software such as R.
Ability to prepare scientific figures using Power Point, Adobe Illustrator, and/or similar programs.

Please apply online at https://aprecruit.ucsf.edu/JPF04736.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300 - $181,800.

Junior, Assistant, Associate, or Full Specialist - McManus Lab

The McManus Lab at University of California, San Francisco is seeking a Lab Specialist at the Junior, Assistant, Associate, or Full rank, depending on qualifications. One focus of our research is to determine the mechanisms for gene regulation and function in mouse models, illuminating connections between genes and development/disease. The candidate will be working in a small team who are engaged in basic research.

This is a full-time position at UCSF and ideal position for applicants interested in working with laboratory mice. To learn about our science, visit our websites at: http://mcmanuslab.ucsf.edu

Responsibilities:

Perform molecular biology techniques including DNA extraction, PCR, plasmid preparation and basic cloning.
Oversee transgenic mouse colony maintenance.
Perform dissections and collect embryos and adult mouse tissues as needed.
Record keeping and data entry.
Perform other duties as assigned.

Required Qualifications:

Specialists appointed at the junior rank must possess (or in process of obtaining) a baccalaureate degree (or equivalent degree) in biological/biochemical science or related field or must have at least four years of research experience in a related field.
Specialists appointed at the Assistant rank must possess (or in process of obtaining) a master’s degree in biological/biochemical science or related field or a baccalaureate degree with 3 or more years of research experience.
Specialists appointed at the Associate rank must possess (or in process of obtaining) a master’s degree (or equivalent degree) in biological/biochemical science or related field or must have at least five to ten years of experience in the relevant specialization.
Specialists appointed at the Full rank must possess (or in process of obtaining) a terminal degree (or equivalent degree) in biological/biochemical science or related field or must have at least ten or more years of experience in the relevant specialization.
Appointees at the Associate and Full level must have significant record of academic accomplishment including published or in-press publication, and a demonstrated record of University and/or public service.
Applicant’s materials must list (pending) qualifications upon submission.
Applicants must have obtained the degree requirement for the Specialist rank by the time of hire.
Ability to work under minimal supervision.
Strong organization, and oral/written communication skills.

Preferred Qualifications:

Previous experience in animal husbandry.
Knowledge of and experience with basic molecular biology protocols.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300 - $181,800.

Please apply online at https://aprecruit.ucsf.edu/JPF04680.

Junior or Assistant Specialist - Ricardo-Gonzalez Lab

Department of Dermatology

Job Description
The Ricardo-Gonzalez Lab (rrglab.com) is a recently established immunology laboratory interested in understanding how tissue-resident immune cells influence tissue physiology and function. The research specialist will perform basic and translational research to investigate the role of innate and adaptive immune cells in tissue homeostasis and models of infection, inflammation, and cancer. We seek a specialist who will assist the team by performing laboratory and investigative procedures using a wide array of experimental techniques such as flow cytometry, immunofluorescence imaging, PCR, cell culture (cell lines and primary cells), plasmid prep and purification, molecular cloning, and ELISA-like assays. Translational research components will involve experiments with human blood and tissue samples. Specialist responsibilities regarding mouse model systems will include breeding, screening, and immunizing mice as well as dissecting tissues to obtain cells for culture and analysis of gene expression.

Required Qualifications:

Excellent organizational skills
Willingness and ability to learn new methods and skills as needed for changing research priorities.
Ability to work independently and as a member of a research team.
Must be organized and have the ability to prioritize tasks, coordinate work tasks with others, and manage to meet multiple deadlines.
Ability to maintain a comprehensive laboratory notebook of experiments done on a daily basis.
Demonstration of accuracy and attention to detail in sample preparation during prior research experience is required.
Excellent interpersonal communication, ability to consent and recruit patients for the studies.
Ability to use or learn to enter information into REDCap database.
Specialist appointed at the Junior rank must possess (or be in process of obtaining) a bachelor’s degree (or equivalent degree) in biology, biochemistry, or a related scientific discipline or four years of research experience.
Specialists appointed at the Assistant rank must possess (or be in process of obtaining) a master’s degree (or equivalent degree) in biology, biochemistry, or a related scientific discipline or a bachelor’s degree in biology, biochemistry, or a related scientific discipline with three or more years of research experience.
Candidates must meet the requirements by the time of appointment.

Preferred Qualifications:

Experience with mouse models of human disease
Experience with cell culture and sterile technique
Experience with infectious disease models in mice
Computational biology coursework and/or research experience
Flow Cytometry (FACS): Ability to perform multicolor flow cytometry.
Transgenic Mouse Work: Experience with experimental animal research. Comfort with handling, manipulating, euthanizing, and dissecting experimental animals.
Fluorescence Microscopy: Experience with sample preparation, immunofluorescence staining, and use of epifluorescence and confocal microscopes for image acquisition.
Communication, logistical, and time management skills to coordinate work with other lab members.

Licensure/Certification/Registration: None required.

Physical Requirements:

Good visual acuity and accurate color discrimination.
The position requires excellent manual dexterity and familiarity utilizing delicate instrumentation.
Occasionally lifts and/or carries objects weighing up to 20 pounds.
Work involves possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances.
Long periods of standing and/or sitting.

Please apply online at https://aprecruit.ucsf.edu/JPF04888, and submit a CV, cover letter and 3 reference contacts.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$65,900.

Junior or Assistant Specialist- Shokat Lab

Department of Cellular & Molecular Pharmacology

During your time in my laboratory, you will work closely with a postdoctoral fellow and a CCB graduate student in my laboratory, on the chemical synthesis and biological evaluation of covalent drug candidates targeting the most commonly mutated oncogene KRAS. To this end you will be using methods ranging from organic chemistry, in vitro biochemistry (protein expression, GTPase assays, intact protein mass spec), to cell biology (work with cancer cell lines, western blots, viability assays, imaging). You will have the opportunity to do translational research and explore new methods as part of your training before pursuing the next steps in your career.

Required Qualifications

Specialists appointed at the junior rank must possess a bachelor’s degree (or equivalent degree) or at least four years of research experience.
Specialist appointed at the Assistant rank must possess a master’s degree or a bachelor’s degree with 3 or more years of research experience.
Excellent verbal and written communication skills
Scientific lab experience and comfort
Ability and desire to learn new experimental approaches
Candidates must meet the required qualifications at the time of appointment.
Candidate's CV or cover letter must state required qualifications (or if pending) upon submission.

Preferred Qualifications

Basic skills on designing and performing synthesis of organic molecules, and their characterizations.
Experience with molecular cloning and recombinant protein purification.
Knowledge of biochemical assays, for example mass spectrometry-based covalent protein labeling, and fluorescence-based protein-protein interaction, etc.
Experience with computational chemistry for discovery of small molecule ligand of protein targets.
Common problems solved by the employee:
Molecular cloning of K-Ras mutant oncogenes.
Purification of recombinant K-Ras proteins with various codon 12/13 mutations.
Maintain of a few cancer cell lines.
Less frequent and more complex problems solved by the employee:
Organic synthesis of a library of potential covalent modifiers of K-Ras(G13C) protein, and characterization of the synthesized compounds.
Biochemical assay of the synthesized compounds using mass spectrometry, and interpretation of the outcome data.
Problems/situations that are referred to this employee's supervisor:
Complex experimental designs or procedures that require additional expertise or resources.
Unforeseen technical difficulties or unexpected results that require troubleshooting and problem-solving skills.

Please apply online at https://aprecruit.ucsf.edu/JPF04469, with a CV, cover letter, and three reference contacts.

Junior/Assistant/Associate/Full Specialist - Nystul Lab

The Nystul lab is seeking a Junior/Assistant/Associate/Full Specialist to join our group and contribute to new and ongoing projects. Our lab focuses on epithelial stem cells using Drosophila melanogaster as a model. The successful applicant will design and perform experiments to investigate mechanisms of competition for an epithelial stem cell niche using the Drosophila as a model. The applicant will develop a detailed understanding of Drosophila genetics, Drosophila oogenesis, stem cell biology, and epithelial biology. An exceptional candidate will lead their own independent project, develop new ideas, be familiar with the literature, and participate in procurement of funds, where appropriate. Additionally, the specialist will be expected to assist with managing day-to-day lab operations, and perform general lab duties and be a positive lab citizen.

Required Qualifications:

Excellent organizational and interpersonal communication skills (verbal and written)
Willingness and ability to learn new methods and skills for changing research priorities.
Ability to work independently and as a member of a research team.
Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.
Must have (or be in process of obtaining) a baccalaureate degree (or equivalent degree) or four years of research experience to be appointed at the Junior rank.
Must have (or be in process of obtaining) a master’s degree (or equivalent degree) or a baccalaureate degree with three or more years of research experience to be appointed at the Assistant rank.
Must have (or be in process of obtaining) a master’s degree (or equivalent degree) or at least five to ten years of research experience to be appointed at the Associate rank.
Must have (or be in process of obtaining) a terminal degree (or equivalent degree) or at least ten or more years of research experience to be appointed at the Full rank.

Preferred Qualifications:

Experience with laboratory research using Drosophila as an experimental model
Experience with whole-mount tissue immunofluorescence
Knowledge of the developmental properties of cells and tissues
Experience with identifying and reviewing relevant scientific literature
Experience with developing and writing wet-lab protocols
Knowledge about research design, ethics in research, and data presentation

We are seeking at least a 1-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available.

Applicants must meet requirements by the time of appointment.

Please apply online at https://aprecruit.ucsf.edu/JPF04928.

Junior Specialist - Padmanabahn Lab

The Padmanabhan Lab is now recruiting a Junior Specialist. The areas of specialization and responsibilities for this position include:
• Culture and genetically manipulate mouse embryonic stem (mES) and human induced pluripotent stem (hIPS) cells and perform directed differentiation to atrial and ventricular cardiomyocytes.
• Design, generate, and validate novel genotyping protocols for engineered mouse genetic alleles and cell lines.
• Assessment gene expression by quantitative PCR.
• Perform timed matings and dam dissections to isolate mouse embryos at various stages of development.
• Perform rapid DNA isolation and genotyping of mouse embryos immediately following sample collection.
• Process embryonic and adult tissues for histologic evaluation.
• Perform standard molecular biology and biochemistry techniques (including molecular cloning, virus preparation and in vitro/in vivo viral transduction, Western blotting, immunoprecipitation, co-immunoprecipitation, and chromatin immunoprecipitation).
• Organize and actively maintain a mouse colony of 80-100 cages.
• Collaborate with other laboratory staff to rapidly complete necessary tasks and move research program forward.
• Maintain a pristine laboratory notebook and organize all collected data and samples appropriately.
• Perform basic statistical analysis, organize collected data into a presentable format, and summarize findings in narrative form.

Required qualifications:
• Bachelor’s Degree in Biological Sciences, Bioengineering, or related fields.
• At least 1-year of experience working in a research laboratory in either academia or industry settings.
• Knowledge of cell culture, standard molecular biology and biochemistry techniques, and in vivo mouse modeling.
• Demonstrated ability to contribute data to ongoing research efforts.
• Skill in independently resolving broad problems that may arise in collection or analysis of laboratory data.
• Self-motivated with ability to work independently and as part of a team.
• Able to learn effectively and meet deadlines.
• Demonstrated effective communication and interpersonal skills.
• Proven ability to successfully work on multiple concurrent projects.
• Ability to effectively manage their time.
• Proven ability to understand research cycles and rapidly perform experiments necessary for manuscripts in revision.
• Interest and proven ability to work closely with other members of the team towards carrying out the broader goals of the laboratory.

Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service. Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary will be commensurate with the applicants experience and training.

Please apply online at https://aprecruit.ucsf.edu/JPF04804. Applicants’ materials must list current and/or pending qualifications upon submission.

Junior/Assistant/Associate/Full Specialist - Sneddon Lab

The Department of Cell and Tissue Biology is seeking a highly motivated full-time non-faculty Academic Specialist to join The Sneddon Lab. Selected candidates will be appointed at the level of Junior, Assistant, Associate or Full Specialist depending on qualifications.

Founded in 1881, the UCSF School of Dentistry has striven to educate the leading practitioners, scholars and faculty members of the next generation. As a leading institution of oral and craniofacial health, our educational programs have grown to include, in addition to our DDS programs, an array of PhD, post-graduate and residency programs. Our student dentists, residents and faculty handle over 120,000 patient visits a year in our comprehensive UCSF Dental Center, and our students staff numerous community-based externship sites. The school is one of the top oral and craniofacial research enterprises in the world, ranked the top dental school in the country in research funding from the National Institutes of Health for 25 years, and home to several leading translational research programs.

The Department of Cell and Tissue Biology (CTB) is a basic science department within the School of Dentistry. The department was established in 2005 and includes 15 faculty with primary appointments and five faculty with secondary appointments. Additionally, the department is home to numerous postdoctoral fellows as well as graduate students in programs ranging from Biomedical Sciences, Tetrad and Biophysics to Developmental & Stem Cell Biology and Oral & Craniofacial Sciences. Faculty research interests include cell biology mechanisms relevant to cytoskeletal dynamics, development, metabolism, cancer, immunology and neurobiology.

Description:
The primary focus of the Sneddon laboratory is pancreatic development and type 1 diabetes, and we employ the tools of stem cell biology, developmental biology, genomics, and tissue engineering. The candidate will be expected to contribute to ongoing work in these areas, with specific duties including human embryonic stem cell culture, mouse husbandry and transplantations, FACS analysis, and genomics techniques. The position represents an opportunity to be at the cutting edge of translational research in a highly collaborative scientific environment.

Additionally, the specialist will be expected to assist with managing day-today lab operations, perform general lab duties, and act as a supportive and positive lab citizen.

Please apply online at https://aprecruit.ucsf.edu/JPF04439

Junior/Assistant/Associate/Full Specialist – Feinberg Lab

The Feinberg lab is seeking a Junior/Assistant/Associate/Full Specialist to join our group and contribute to new and ongoing projects. Our lab focuses on sensorimotor integration in mice. The candidate will be expected to assist graduate students and postdoctoral fellows in performing behavioral experiments in mice. Responsibilities may include performing stereotaxic surgeries to deliver viruses and drugs to specific anatomic sites in the mouse brain; performing two-photon calcium imaging in the brains of awake, behaving mice; performing immunostaining of brain slices to characterize gene expression in the nervous system; running behavioral assays in conjunction with optogenetics or in vivo calcium imaging; genotyping and mouse colony maintenance and perform other duties as assigned. Additionally, the specialist will be expected to assist with managing day-to-day lab operations, and perform general lab duties and be a positive lab citizen.

Required Qualifications:
• Excellent organizational and interpersonal communication skills (verbal and written)
• Willingness and ability to learn new methods and skills for changing research priorities.
• Ability to work independently and as a member of a research team.
• Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.
• Must have (or be in process of obtaining) a bachelor’s degree (or equivalent degree) or four years of research experience to be appointed at the Junior rank.
• Must have (or be in process of obtaining) either a Master’s degree or a Bachelor’s degree with 3+ years of research experience to be appointed at the Assistant rank.
• Must have (or be in process of obtaining) a master’s degree (or equivalent degree) or five to ten years of research experience to be appointed at the Associate rank.
• Must have (or be in process of obtaining) a terminal degree (or equivalent degree) or at least ten or more years of research experience to be appointed at the Full rank.

Preferred Qualifications:
• Prior experience in handling mice and stereotaxic procedures
• Prior experience in analyzing experimental data in MATLAB and/or Python.

We are seeking at least a 1-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available.

Applicants must meet requirements by the time of appointment.

Please apply online at https://aprecruit.ucsf.edu/JPF04418

Junior or Assistant Specialist - Roose Lab

The Roose lab is seeking a Junior or Assistant Specialist to join our group and contribute to new and ongoing projects. The Roose lab focuses on understanding cell fitness and cell fate decisions driven by cell-cell interactions and signaling pathways, in the context of stem cell biology, cancer, and autoimmune diseases. In our leukemia work, we focus on developing a new in vitro system so that we can grow (and developmentally track) human leukemias and explore therapy development.

The candidate will be expected to contribute to this new in vitro system, termed bone marrow organoids. The work will have very stong emphasis on hydrogel strategies and other bioengineering technologies to develop bone marrow organoids, but also cell culture of leukemia cell lines, primary leukemia cultures, imaging, and spectral flow. An exceptional candidate will lead their own independent project, develop new ideas, be familiar with the literature, and write up results and generate figure panels. Additionally, the specialist will be expected to assist with managing day-to-day lab operations, and perform general lab duties and be a positive lab citizen.

Required Qualifications:

Must have (or be in process of obtaining) a bachelor’s degree (or equivalent degree) or four years of relevant research experience to be appointed at the Junior rank.
Must have (or be in process of obtaining) a master’s degree or a baccalaureate degree with 3 or more years of research experience
Experience with cell and tissue culture is a must. Affinity with tissue engineering, biomaterials and biomaterials processing is preferred.
Excellent organizational and interpersonal communication skills (verbal and written).
Willingness and ability to learn new methods and skills for changing research priorities.
Ability to work independently and as a member of a multidisciplinary team with researchers at various academic levels.
Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.

Preferred Qualifications:

Prior experience in synthesis of polymers, photo-responsive hydrogels (syntetic and natural derived or inspired), and cell encapsulation.
Prior experience with biomaterials processing, in particular additive and layer-less printing techniques.
Experience with imagine modalities such as uCT scan, confocal and bright field microscopy is desired.

We are seeking at least a 1-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available.

Applicants must meet requirements by the time of appointment.

Please apply online at https://aprecruit.ucsf.edu/JPF04496

Junior/Assistant/Associate/Full Specialist - Mukherjee Lab

The candidate will be responsible for laboratory research duties as well as lab management duties. This position will involve experiments including bacterial culture, mammalian cell culture, macrophage infections, microscopy, molecular biology, gene expression analysis, mammalian cell transfections, immunoprecipitations, protein gels, Western blotting; and perform other duties such as lab ordering/organization. The specialist will perform experiments with the bacterial pathogen Legionella pneumophila. General lab managerial tasks such as cataloging and ordering reagents are part of the position, and other duties as assigned. In addition independent research projects are available separate from the above describe duties. The Mukherjee lab is a highly collaborative space that is pushing the cutting edge of host-pathogen biology. Additionally, the specialist will be expected to assist with managing day-to-day lab operations, and perform general lab duties and be a positive lab citizen.

Required Qualifications:
• Excellent organizational and interpersonal communication skills (verbal and written)
• Willingness and ability to learn new methods and skills for changing research priorities.
• Ability to work independently and as a member of a research team.
• Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.
• Must have (or be in process of obtaining) a bachelor’s degree (or equivalent degree) or four years of research experience to be appointed at the Junior rank.
• Must have (or be in process of obtaining) either a Master’s degree or a Bachelor’s degree with 3+ years of research experience for appointment to the Assistant rank.
• Must have (or be in process of obtaining) a master’s degree (or equivalent degree) or at least five to ten years of research experience to be appointed at the Associate rank.
• Must have (or be in process of obtaining) a terminal degree (or equivalent degree) or at least ten or more years of research experience to be appointed at the Full rank.

Preferred Qualifications:
• Prior experience with handling pathogenic microbes, aseptic techniques
• Prior experience in the design and assembly of DNA constructs

We are seeking at least a 2-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available.

Applicants must meet requirements by the time of appointment.

Please apply online at https://aprecruit.ucsf.edu/JPF04433

Junior/Assistant/Associate/Full Specialist - Sil Lab

The Sil lab is seeking a Junior/Assistant/Associate/Full Specialist to join our group and contribute to new and ongoing projects. Our lab focuses on the basic biology of fungal pathogens and their interaction with innate immune cells. We are interested in understanding how these pathogens respond to their environment and how they manipulate the immune system. We take a number of molecular approaches, including genetics and genomics. The candidate will be expected to generate genetic tools and conduct microbiology and molecular biology techniques, including fungal and macrophage manipulation, cloning, protein purification, and biochemical assays. An exceptional candidate will lead their own independent project, develop new ideas, be familiar with the literature, and participate in procurement of funds, where appropriate. Additionally, the specialist will be expected to assist with managing day-to-day lab operations, and perform general lab duties and be a positive lab citizen.

Required Qualifications:

Excellent organizational and interpersonal communication skills (verbal and written)
Willingness and ability to learn new methods and skills for changing research priorities.
Ability to work independently and as a member of a research team.
Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.
Must have (or be in process of obtaining) a bachelor’s degree (or equivalent degree) or four years of research experience to be appointed at the Junior rank.
Must have (or be in process of obtaining) a master’s degree or a baccalaureate degree with three or more years of research experience to be appointed at the Assistant rank.
Must have (or be in process of obtaining) a master’s degree (or equivalent degree) or five to ten years of research experience to be appointed at the Associate rank.
Must have (or be in process of obtaining) a terminal degree (or equivalent degree) or at least ten or more years of research experience to be appointed at the Full rank.

Preferred Qualifications:

Prior experience with handling pathogenic microbes, aseptic techniques
Prior experience in the design and assembly of DNA constructs
Prior experience in molecular genetics and biology (i.e. gene knockouts, epitope tagging, immunoprecipitation, protein-protein interactions)
Prior experience with RNAseq
Prior experience with murine macrophage differentiation and infection
Prior experience working with fungi

We are seeking at least a 2-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available.

Applicants must meet requirements by the time of appointment.

Please apply online at https://aprecruit.ucsf.edu/JPF04646

Research Specialist – Rosenblum Lab

The Rosenblum Lab in the Department of Dermatology at UC San Francisco is seeking a Research Specialist at the Junior, Assistant, or Associate level. We are a basic immunology laboratory that studies how the immune system functions in both mouse and human skin. Our research focuses on regulatory T cells (Tregs), an immune cell type critical for preventing autoimmunity. We seek to understand how Tregs influence homeostasis, inflammation, tissue repair, and cancer by interacting with other immune cells, parenchymal cells, and stem cells in the skin.

This position requires a 2-year commitment and will consist of hands-on laboratory research (100% time commitment). Research will primarily involve assisting post-doctoral fellows, graduate students, and staff working on basic immunology projects, with the opportunity to learn skills such as mouse dissection, flow cytometry, confocal microscopy, CyTOF, bulk and single-cell RNA sequencing, and spatial transcriptomics. There will be opportunities to eventually drive/direct an independent research project.

Appointees in the Specialist series will be expected to engage full-time in research and professional activities and will not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service.

Specialists appointed at the Junior rank must possess a bachelor’s degree (or equivalent degree) or at least four years of equivalent research experience (e.g., with instrumentation and research equipment, social science research methods, or creative activities). Specialists appointed at the Assistant rank must possess a master’s degree or a bachelor’s degree with 3 or more years of research experience. Specialists appointed at the Associate rank must have a master’s degree (or equivalent degree) or five to ten years of research experience.

Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Optimal start date for the position is immediately. Please apply online at ###.

Please apply online at https://aprecruit.ucsf.edu/JPF04581

Junior Specialist – Oskowitz Lab

The Oskowitz lab at the University of California, San Francisco (UCSF) is seeking independent and creative researchers to join a fast-moving project developing a therapeutic for the treatment of aortic aneurysms. Funded by the National Institutes of Health (NIH) and the American Heart Association (AHA), the Oskowitz lab is focused on translational research for cardiovascular disease. The Oskowitz laboratory occupies approximately 1,000 sq. ft. on the 2nd floor of the Smith Cardiovascular Research Building (SCVRB) on the Mission Bay UCSF campus. The five story, SCVRB was opened in 2010 as the primary home of the UCSF Cardiovascular Research Institute investigators and is a state-of-the-art biomedical research facility. The top floor of SCVRB is a fully equipped vivarium including procedure and surgical suites. The lab has exclusive access to a small animal microsurgery suite on the 5th floor of the SCVRB.

In collaboration with the Principal Investigator, Dr. Adam Oskowitz and other senior scientists in the lab, the Specialist will focus on research investigating a treatment of abdominal aortic aneurysms. This will include basic molecular biology, cell culture, small animal surgery and in vivo work, large animal surgery and tissue acquisition. The Specialist will be integrated into a team of researchers focused on bringing a novel biotechnology from discovery to a first-in-human clinical trial and as such the work will have critical timelines and milestones.

Initially, the Specialist will work under direct supervision. After a period of onboarding, the Specialist may be given the opportunity for more independent research efforts depending on the level of competence and comfort. The Specialist will be expected to work onsite in the Oskowitz lab 5 days a week (Monday-Friday).

Specialists appointed at the Junior rank must have a baccalaureate degree (or equivalent degree) in biology, pharmacology, chemistry, bioengineering, or a related field or at least 4 years of experience with Molecular biology including RNA and protein-based assays animal models and in vivo work including tissue harvest, specimen collection, histology, and blood processing.

Specialist appointed at the Assistant rank must have a master’s degree (or equivalent degree) in biology, pharmacology, chemistry, bioengineering, or a related field or a baccalaureate degree with 3 or more years of years of experience with Molecular biology including RNA and protein-based assays animal models and in vivo work including tissue harvest, specimen collection, histology, and blood processing.

Specialist appointed at the Associate rank must have a master’s degree (or equivalent degree) in biology, pharmacology, chemistry, bioengineering, or a related field or at least 5 to 10 years of experience with Molecular biology including RNA and protein-based assays animal models and in vivo work including tissue harvest, specimen collection, histology, and blood processing.

Specialist appointed at the Full rank must have a PhD (or equivalent degree) in biology, pharmacology, chemistry, bioengineering, or a related field or at least 10 or more years of experience with Molecular biology including RNA and protein-based assays animal models and in vivo work including tissue harvest, specimen collection, histology, and blood processing.

Applicants who have significant experience with multi-channel flow cytometry or FACS, experience preforming small animal surgery or tissue harvest, experience with advanced microscopy and image analysis or experience with in vivo imaging or localization studies are strongly encouraged to apply.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $49,000 - $173,900.

Please apply online at https://aprecruit.ucsf.edu/JPF04564.

Junior Specialist – Turnbaugh Lab

The Turnbaugh lab is seeking a Junior Specialist to join our group and contribute to new and ongoing projects. This work will focus on the study of the microbiome using Gnotobiotic mice, and will include performing advanced experimental techniques to execute experiments (for example, the Specialist may administer experimental agents via oral, i.p., or subcutaneous routes, and follow up with experimental disease scoring and tracking, dissection and processing of tissues, or other techniques deemed experimentally necessary). Lab techniques performed by the Specialist include (but are not limited to): DNA extraction, PCR, qPCR, microbial cultures, gram staining, and genotyping. The candidate will also be expected to contribute to novel projects advancing research and development of Gnotobiotic tools. For example, the candidate will work on the development of novel models (such as allergy and asthma) in sterile mice and the translation of embryo-transfer techniques into a germ-free setting, among other projects. An exceptional candidate will move these projects forward independently, helping the lab to develop and test new ideas. Additionally, the specialist will be expected to assist with managing day-to-day lab operations within the Gnotobiotic core facility, perform general lab duties, and be a positive lab citizen.

Preferred Qualifications:
• Prior experience with handling pathogenic microbes, aseptic techniques
• Prior experience working in a research-based setting with murine models
• Prior experience in gnotobiotic mouse handling/maintenance in positive pressure isolators, with a focus on sterility
• Prior experience in advanced techniques in murine models (such as injection of compounds, oral gavage, anesthesia, surgery techniques and documentation)

We are seeking at least a 1-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available.

Applicants must meet requirements by the time of appointment.

Please apply online at https://aprecruit.ucsf.edu/JPF04523, https://aprecruit.ucsf.edu/JPF04669, or https://aprecruit.ucsf.edu/JPF04892

Junior Specialist – Chorba Lab

The Chorba Lab seeks a highly motivated Junior Specialist to work as a research technician and laboratory administrator. Under direct supervision and training, the Junior Specialist will work on several highly collaborative projects including 1) the role and druggability of the processing and trafficking pathways of PCSK9 in regulating the LDL receptor, 2) the characterization of CSDE1 as a regulator of LDLR mRNA decay, and 3) the development of methods to chemically perturb protein translation in a sequence specific manner. The incumbent for this position will have many duties relevant to these goals, including the generation of DNA constructs, generation and maintenance of cell lines, and production and purification of recombinant proteins, in addition to standard cell culture and molecular biology techniques. Responsibilities also include assisting with all routine laboratory maintenance (restocking of supplies, assisting with monitoring freezers, and additional duties as necessary). Notably, the successful candidate may be required to attend to cell culture samples or experimental procedures at off-hours or on weekends when necessary.

The successful candidate for this position will have a background in general biology, molecular biology, cell biology, genetics, and chemistry. They will be involved in analyzing the effects of chemical and biochemical perturbations of specific proteins both in vitro and in cells. This work will require a number of biochemical and biologic techniques including (but not limited to): PCR; DNA and protein gel electrophoresis; Western blotting; standard cell culture; flow cytometry; transfections; DNA/RNA extractions; protein purification; buffer preparation; and microplate assays. The candidate must have clear knowledge of molarity, sterile technique, standard Mendelian genetic inheritance, general microbiology, and the central dogma of molecular biology. Specialists appointed at the junior rank must possess a baccalaureate degree (or equivalent degree) or at least four years of relevant research experience (e.g., with instrumentation and research equipment, social science research methods, or creative activities).

Our research efforts are focused on identifying and validating drug targets and developing novel therapeutic strategies to treat cardiovascular disease, with a particular focus on regulators of lipid metabolism and cholesterol levels. To this end, we pursue the molecular mechanisms of how key players in these pathways interact, and how their dysregulation leads to disease. Our work bridges the interface of chemistry and biology, where we develop cutting-edge chemical, biochemical, and genetic tools to pursue our inquiries. We are an inclusive environment and are not afraid to think big.

Please apply online at https://aprecruit.ucsf.edu/JPF04472. Applicants’ materials must list current and/or pending qualifications upon submission.

Junior Specialist – Al-Sady Lab

The Al-Sady lab is seeking a Junior Specialist to join our group and contribute to new and ongoing projects. Our lab focuses on understanding the dynamics of repressive chromatin domains. We are particularly interested in the biochemical mechanisms my which “write” enzymes that depot reprseve hstone marks engage with their chromatin substrate and propagate repressive information along the chromosome. The candidate will be expected to contribute to the production and development of chromatin related tools for their project but also for other lab members and develop their own research project around the study of chromatin enzyme mechanisms. This will require cloning, bacterial expression, protein purification and enzymological and biochemical assays. An exceptional candidate will lead their own independent project, develop new ideas, be familiar with the literature, and participate in procurement of funds, where appropriate. Additionally, the specialist will be expected to assist with managing day-to-day lab operations, and perform general lab duties and be a positive lab citizen.

Preferred Qualifications:
• Prior experience with handling protein prufication equipment such as FPLC or gravity columns
• Prior experience in the design and assembly of DNA constructs
• Prior experience with recombinant protein expression
• Prior experience with biophyisical approaches such as protein-protein interaction methods
• General familiarity with concepts in protein biochemistry

We are seeking at least a 1-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available.

Applicants must meet requirements by the time of appointment.

Please apply online at https://aprecruit.ucsf.edu/JPF04476. Applicants’ materials must list current and/or pending qualifications upon submission.

Junior Research Specialist - Nayak Lab

The Nayak Lab (nayak.ucsf.edu) has an opening for a junior research specialist who is interested in advancing our knowledge of the gut microbiome and its impact on rheumatic diseases, such as rheumatoid arthritis. We use multiple state-of-the-art technologies, including bacterial genomics, metabolomics, anaerobic microbiology, bacterial genetics, gnotobiotic animal models, and studies of patient cohorts to elucidate the mechanisms by which gut microbiota impact patient response to treatment of rheumatic disease. A major driving force of the lab is the advancement of precision medicine for patients with rheumatic disease.

The candidate will contribute to new and ongoing projects in the lab. The candidate will use or learn a variety of techniques in anaerobic microbiology, microbial genomics, analytical chemistry, molecular biology, cell culture, mouse work, computational analysis, and immunology. Additionally, the specialist will be expected to assist with managing day-to-day lab operations, perform general lab duties, and be a positive lab citizen. Candidates will be expected to work independently and be active contributors to the collaborative multidisciplinary team of microbiologists, immunologists, and computational biologists. The successful candidate will report directly to Dr. Renuka Nayak, MD, PhD but will work closely with collaborators within and outside of the group. An exceptional candidate will lead their own independent project, develop new ideas, be familiar with the literature, and participate in procurement of funds, where appropriate. Candidates interested in pursuing MD, PhD, or MD/PhD. training will benefit most from this laboratory experience.

Required Qualifications:
• Excellent organizational and interpersonal communication skills (verbal and written).
• Willingness and ability to learn new methods and skills for changing research priorities.
• Ability to work independently and as a member of a research team.
• Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.
• Familiarity with standard wet lab techniques (e.g. preparation of reagents/chemicals, basic microbiology, tissue culture, PCR, western blot, DNA/RNA purification) and/or computational analysis of large datasets.
• Must have (or be in process of obtaining) a bachelor’s degree (or equivalent degree) or four years of research experience.

Preferred Qualifications:
• Prior experience with handling pathogenic microbes, aseptic techniques
• Prior experience in high throughput sequencing and analysis
• Prior experience in mass spectrometry or other analytical chemistry approaches
• Prior experience in flow cytometry or other immune profiling methods
• Prior experience in the design and assembly of DNA constructs
• Prior experience in bacterial genome manipulation
• Prior experience working with mice

We are seeking at least a 2-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available. Applicants must meet requirements by the time of appointment.

The Nayak Lab is located at the San Francisco VA Medical Center, perched atop Land’s End and overlooking the San Francisco Bay. We are a part of the University of California, San Francisco (UCSF) Benioff Center for Microbiome Medicine (BCMM), enabling engagement with a rich community of investigators and access to cutting-edge resources for promoting microbiome research.

Please apply online at https://aprecruit.ucsf.edu/JPF04699. Applicants’ materials must list current and/or pending qualifications upon submission.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$54,600.

Junior/Assistant/Associate Specialist – Lakkaraju lab

The Department of Ophthalmology at the University of California, San Francisco, is currently accepting applications for a Junior/Assistant/Associate Specialist in the laboratory of Dr. Aparna Lakkaraju. Our research focuses on identifying pathological mechanisms and developing therapeutics for age-related macular degeneration (AMD), a complex neurodegenerative disease that destroys high-resolution central vision in over 50 million older adults. The candidate will join an interdisciplinary team of scientists to evaluate novel therapeutic targets in mouse models of disease.

This is a full-time position ideal for applicants interested in developing mouse models of disease to evaluate pathology and potential drug candidates. To learn about our science, visit: https://ophthalmology.ucsf.edu/lakkarajulab/

Responsibilities include the following:

Manage transgenic mouse colonies, including breeding and genotyping.
Perform routine biochemical, molecular biology, and confocal microscopy experiments.
Design and execute studies in mouse models.
Generate and maintain primary cell cultures.
Perform data analysis, record keeping.
Participate in grant and manuscript writing.
Present findings at national and international meetings.
Mentor trainees as needed.

Required Qualifications:

Specialists appointed at the junior rank must possess (or in process of obtaining) a baccalaureate degree (or equivalent degree) in biological/biochemical science or related field or must have at least four years of research experience in a related field.
Specialists appointed at the Assistant rank must possess (or in process of obtaining) a master’s degree (or equivalent degree) in biological/biochemical science or related field or must have a baccalaureate degree with three or more years of research experience.
Specialists appointed at the Associate rank must possess (or in process of obtaining) a master’s degree (or equivalent degree) in biological/biochemical science or related field or must have at least five – ten years of experience in the relevant specialization.
Appointees at the Associate level must have significant record of academic accomplishment including published or in-press publication, and a demonstrated record of university and/or public service.
Applicants’ materials must list current and/or pending qualifications upon submission.
Applicants must have obtained the degree requirement for the Specialist rank by the time of hire.
Hands-on experience working with rodents.
Proficiency in designing, executing, and analyzing in vivo experiments.
Experience with standard molecular and cell biology techniques including cell culture, western blotting, microscopy, PCR, genotyping, cloning.

Preferred Qualification:

Experience with ocular disease models is preferred.

Screening of applicants will begin immediately and will continue as needed throughout the recruitment period.

Salary will be commensurate with the applicants experience and training.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $49,000 - $78,500.

Please apply online at https://aprecruit.ucsf.edu/JPF04548.

Junior/Assistant/Associate/Full Specialist - Tymofiyeva Lab

The Tymofiyeva lab is looking for a Junior, Assistant, Associate, or Full Specialist who is enthusiastic and motivated to join our lab focused on adolescent neuroimaging and adolescent mental health. In particular, the successful candidate will be assisting with recruitment, MRI scans, and psychometric assessments of study participants, as well as with data analyses. In addition, the applicant will be expected to attend regular lab meetings and to perform additional duties in the lab as needed.

Required Qualifications:

Specialists appointed at the Junior rank must possess a bachelor’s degree (or equivalent degree) in biology, biomedical imaging, psychology or related sciences or at least four years of research experience.
Specialists appointed at the Assistant rank must possess a master’s degree (or equivalent degree) or a bachelor’s degree with three or more years of research experience.
Specialists appointed at the Associate rank must possess a master’s degree (or equivalent degree) or five to ten years of research experience.
Specialists appointed at the Full rank must possess a terminal degree (or equivalent degree) or ten or more years of research experience.
Applicants must meet all the qualifications by the time of hire.
Candidate’s CV and/or cover letter must state qualifications (or if pending) upon submission.
One or more years of research work in the field of mental health of adolescents ages 14-18 with and without clinical diagnoses of depression and anxiety.
One or more years of research work in the field of adolescent suicidality.

Preferred Qualifications:

Training in administering Children's Depression Rating Scale-Revised (CDRS-R)
Ability to organize data and keep detailed records
Knowledge of the principles and procedures of at least one neuroimaging method (e.g., MRI, EEG, MEG) and excellent communication skills (both oral and written) in English
Experience of scoring psychological assessments
Neuroimaging data analysis skills
Excellent organization skill and attention to detail
Excellent time and task management skills
Ability to work effectively in a team environment
Ability to work independently and assess need for assistance from supervisor

Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary and rank will be commensurate with the applicants experience and training.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$181,800.

Please apply online at: https://aprecruit.ucsf.edu/JPF04585 with a cover letter and CV.

Junior or Assistant Specialist - Hernandez Lab

The Department of Bioengineering and Therapeutic Sciences is now recruiting a Junior or Assistant Specialist. The successful candidates will work in the field of population genetics, human genetics, computational/statistical genomics, or a related field. Projects will focus on a range of topics from modeling how evolutionary forces shape patterns of genetic variation to genetic architecture of complex traits to multi-omics analysis of complex diseases. Most work will be computational, though some opportunities for wet lab work will arise. This is primarily a training position. Successful candidates should be interested in exploring a research career. It is anticipated that the successful candidates will apply to graduate schools 1-2 years after joining our group.

Required Qualifications:
• Junior rank- possess a bachelor’s degree (or equivalent degree) or at least four years of relevant research experience.
• Assistant rank- possess a master’s degree (or equivalent degree) or five years of experience in the relevant specialization.
• Must be proficient in one or more programming languages (or excited to gain coding proficiency
• Have statistical training or eager to gain training in statistical thinking
• Have a background in genetics (or a related biological field) or be interested in learning about this field
• Have some prior exposure to computational research (at least 4 weeks in duration).
• Candidate’s must meet the required qualifications at the time of start.
• Candidate’s CV must state qualifications (or if pending) upon submission.

Preferred Qualifications:
• Candidates that are eligible to join the PROPEL training program (propel.ucsf.edu) are especially encouraged to apply.

Please apply online at https://aprecruit.ucsf.edu/JPF04239, with a CV, cover letter, and statement of research, and three reference contacts.

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